Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4811673 | 0.99 | HTR1A (0.66) | HTR1AALDH1A1KDM4ELMNAMCHR1 | |
| SCHEMBL3838003 | 0.88 | ALDH1A1 (0.61) | HTR1AALDH1A1KDM4ELMNASLC6A4 | |
| Hydrochloric Acid SCHEMBL4875943 | 0.87 | ALDH1A1 (0.60) | HTR1AALDH1A1KDM4ELMNASLC6A4 | |
| SCHEMBL4874455 | 0.84 | ALDH1A1 (0.76) | HTR1AALDH1A1KDM4ELMNAMEN1 | |
| SCHEMBL29110683 | 0.76 | L3MBTL1 (0.66) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL20382528 | 0.76 | HTR1A (0.65) | HTR1AALDH1A1KDM4ELMNASLC6A4 | |
| SCHEMBL13342872 | 0.76 | HTR1A (0.65) | HTR1AALDH1A1KDM4ELMNASLC6A4 | |
| SCHEMBL8106834 | 0.76 | HTR1A (0.65) | HTR1AALDH1A1KDM4ELMNASLC6A4 | |
| SCHEMBL15935698 | 0.75 | ALDH1A1 (0.94) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL4501968 | 0.75 | MEN1 (0.58) | HTR1AALDH1A1KDM4ELMNASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1553092-B1 | ARALKYL FORMYL-ALKYL PIPERAZINE DERIVATIVES AND THEIR USES AS CEREBRAL NERVE PROTECTIVE AGENT | SHANGHAI INST PHARM INDUSTRY (CN) | 2009-11-04 | — | — | EP | claimed |
| US-7332495-B2 | Aralkyl-ketone piperazine derivatives and their uses as new antalgic or ataractic agent | NHWA PHARMA. CORPORATION (CN) | 2008-02-19 | — | — | US | claimed |
| US-20060148811-A1 | Aralkyl-ketone piperazine derivatives and their uses as new antalgic or ataractic agent | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2006-07-06 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148811-A1 | Aralkyl-ketone piperazine derivatives and their uses as new antalgic or ataractic agent | AAK1, KCNJ1, KHK | HTR1A 1854/4885ALDH1A1 387/4885KDM4E 1525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.