Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.46 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.45 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.45 |
| ▸ | PHGDH | O43175 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | ALPI | P09923 | 1/20 | 0.40 |
| ▸ | ALPG | P10696 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | TACR3 | P29371 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL94229 | 0.82 | IMPDH2 (0.52) | ROCK2ROCK1IMPDH2ADAMTS4ADAMTS5 | |
| SCHEMBL3039120 | 0.81 | POLB (0.58) | ROCK2ROCK1IMPDH2ADAMTS4ADAMTS5 | |
| SCHEMBL3834428 | 0.81 | ROCK2 (0.49) | ROCK2ROCK1IMPDH2ADAMTS4ADAMTS5 | |
| SCHEMBL3836272 | 0.80 | RAB9A (0.57) | ROCK2IMPDH2ADAMTS4ADAMTS5POLB | |
| SCHEMBL3838597 | 0.79 | IMPDH2 (0.52) | ROCK2ROCK1IMPDH2ADAMTS4ADAMTS5 | |
| SCHEMBL3836954 | 0.77 | IMPDH2 (0.51) | ROCK2ROCK1IMPDH2ADAMTS4ADAMTS5 | |
| SCHEMBL3835811 | 0.77 | POLB (0.56) | ROCK2IMPDH2ADAMTS4ADAMTS5PHGDH | |
| SCHEMBL3835902 | 0.77 | PPARG (0.52) | ROCK2IMPDH2ADAMTS4ADAMTS5PHGDH | |
| SCHEMBL27476988 | 0.77 | NPC1 (0.50) | POLBHDAC8HDAC6ALDH1A1 | |
| SCHEMBL3840595 | 0.75 | KDM4E (0.49) | ROCK2ROCK1IMPDH2ADAMTS4ADAMTS5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |