Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.94 |
| ▸ | HMGCR | P04035 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | ACLY | P53396 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.42 |
| ▸ | CPT2 | P23786 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL22686439 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL66314 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL9405235 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL30541668 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL25196608 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL276989 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL7262312 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL11906205 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL4832768 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL76401 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 206 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024096484-A1 | BIOMARKER FOR DETECTING FOOD POISONING BACTERIA BY USING NEXT-GENERATION SEQUENCING, AND METHOD FOR DETECTING FOOD POISONING BACTERIA BY USING SAME | 대한민국(식품의약품안전처장) | 2024-05-10 | — | — | WO | claimed |
| US-7763420-B2 | administering an Escherichia bacterium strain and detecting the bacterium to indicate the site of proliferation or proliferative conditions selected from tumors, injuries and inflammation | GENELUX CORPORATION (US) | 2010-07-27 | — | — | US | claimed |
| EP-2044436-A2 | METHODS AND COMPOSITIONS FOR DETECTION OF MICROORGANISMS AND CELLS AND TREATMENT OF DISEASES AND DISORDERS | Genelux Corporation (US) | 2009-04-08 | — | — | EP | claimed |
| US-20080193373-A1 | administering an Escherichia bacterium strain and detecting the bacterium to indicate the site of proliferation or proliferative conditions selected from tumors, injuries and inflammation | GENELUX CORPORATION | 2008-08-14 | — | — | US | claimed |
| WO-2008073148-A2 | METHODS AND COMPOSITIONS FOR DETECTION OF MICROORGANISMS AND CELLS AND TREATMENT OF DISEASES AND DISORDERS | GENELUX CORPORATION (US) | 2008-06-19 | — | — | WO | claimed |
| US-20260137088-A1 | COMPOSITIONS OF ENDOPHYTES AND SYNTHETIC ENDOPHYTE CONSORTIA FOR IMPROVING NITROGEN AND PHOSPHORUS UPTAKE, NUTRITION, GROWTH, AND PERFORMANCE IN PLANTS AND METHODS OF MAKING AND USING THE SAME | UNIVERSITY OF WASHINGTON | 2026-05-21 | — | — | US | disclosed |
| EP-4216989-B1 | FORMULATIONS FOR TOPIC MUCOSAL AND/OR ORAL SYSTEMIC ADMINISTRATIONS CONTAINING A MIXTURE BASED ON LACTOFERRIN, MORE EFFECTIVE IN IRON UPTAKE, FOR THE PREVENTION AND TREATMENT OF VARIOUS PATHOLOGIES | MICROBO SRL (IT) | 2026-04-29 | — | — | EP | disclosed |
| EP-4557957-A2 | COMPOSITIONS INCLUDING ENDOPHYTES FOR IMPROVING PLANT NUTRITION, GROWTH, AND PERFORMANCE AND METHODS OF USING THE SAME | Intrincyx Bio Inc. (US) | 2025-05-28 | — | — | EP | disclosed |
| EP-4508192-A2 | COMPOSITIONS INCLUDING ENDOPHYTES FOR IMPROVING PLANT NUTRITION, GROWTH,AND PERFORMANCE AND METHODS OF USING THE SAME | Intrincyx Bio Inc. (US) | 2025-02-19 | — | — | EP | disclosed |
| EP-4489573-A2 | COMPOSITIONS INCLUDING ENDOPHYTES FOR IMPROVING PLANT NUTRITION, GROWTH, AND PERFORMANCE AND METHODS OF USING THE SAME | Intrincyx Bio Inc. (US) | 2025-01-15 | — | — | EP | disclosed |
| WO-2024096484-A1 | BIOMARKER FOR DETECTING FOOD POISONING BACTERIA BY USING NEXT-GENERATION SEQUENCING, AND METHOD FOR DETECTING FOOD POISONING BACTERIA BY USING SAME | 대한민국(식품의약품안전처장) | 2024-05-10 | — | — | WO | disclosed |
| US-20240117446-A1 | FAST DIAGNOSIS AND PERSONALIZED TREATMENTS FOR ACNE | UNIV CALIFORNIA (US) | 2024-04-11 | — | — | US | disclosed |
| EP-0842270-A1 | NUCLEIC ACID AND AMINO ACID SEQUENCES RELATING TO HELICOBACTER PYLORI FOR DIAGNOSTICS AND THERAPEUTICS | AKTIEBOLAGET ASTRA (SE) | 1998-05-20 | — | — | EP | disclosed |
| WO-1998018323-A1 | NUCLEIC ACID AND AMINO ACID SEQUENCES RELATING TO HELICOBACTER PYLORI AND VACCINE COMPOSITIONS THEREOF | ASTRA AKTIEBOLAG (SE) | 1998-05-07 | — | — | WO | disclosed |
| WO-1997019098-A9 | NUCLEIC ACID AND AMINO ACID SEQUENCES RELATING TO HELICOBACTER PYLORI FOR DIAGNOSTICS AND THERAPEUTICS | — | 1997-11-06 | — | — | WO | disclosed |
| WO-1997037044-A1 | NUCLEIC ACID AND AMINO ACID SEQUENCES RELATING TO HELICOBACTER PYLORI AND VACCINE COMPOSITIONS THEREOF | ASTRA AKTIEBOLAG (SE) | 1997-10-09 | — | — | WO | disclosed |
| WO-1997030070-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-08-21 | — | — | WO | disclosed |
| WO-1997019098-A1 | NUCLEIC ACID AND AMINO ACID SEQUENCES RELATING TO HELICOBACTER PYLORI FOR DIAGNOSTICS AND THERAPEUTICS | ASTRA AKTIEBOLAG (SE) | 1997-05-29 | — | — | WO | disclosed |
| WO-1996040893-A1 | NUCLEIC ACID AND AMINO ACID SEQUENCES RELATING TO HELICOBACTER PYLORI FOR DIAGNOSTICS AND THERAPEUTICS | ASTRA AKTIEBOLAG (SE) | 1996-12-19 | — | — | WO | disclosed |
| US-5474905-A | Antibodies specific for streptococcus pneumoniae hemin/hemoglobin-binding antigens | RESEARCH CORPORATION TECHNOLOGIES (US) | 1995-12-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260137088-A1 | COMPOSITIONS OF ENDOPHYTES AND SYNTHETIC ENDOPHYTE CONSORTIA FOR IMPROVING NITROGEN AND PHOSPHORUS UPTAKE, NUTRITION, GROWTH, AND PERFORMANCE IN PLANTS AND METHODS OF MAKING AND USING THE SAME | PPP6R3, PPP6R1, SLC6A4 | MEN1 1516/4885ALDH1A1 4817/4885HMGCR 3929/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.