SCHEMBL38407

SCHEMBL38407

Nc1nc2c(ncn2-n2cnc3c(=O)nc[nH]c32)c(=O)[nH]1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
XDH P47989 8/20 0.47
PNP P00491 4/20 0.44
TK1 P04183 2/20 0.44
BLM P54132 2/20 0.43
USP2 O75604 1/20 0.43
TSHR P16473 1/20 0.43
EDNRA P25101 1/20 0.43
HTR2A P28223 1/20 0.43
RECQL P46063 1/20 0.43
HBB P68871 1/20 0.43
HSD17B10 Q99714 1/20 0.43
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
ALDH1A1 P00352 1/20 0.42
LMNA P02545 1/20 0.42
CYP3A4 P08684 1/20 0.42
NFKB1 P19838 1/20 0.42
VCP P55072 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
HIF1A Q16665 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL986800 0.84 XDH (0.60) XDHPNPTK1BLMUSP2
SCHEMBL15005119 0.83 XDH (0.59) XDHPNPTK1BLMUSP2
SCHEMBL28088511 0.81 TK1 (0.44) XDHPNPTK1BLMUSP2
SCHEMBL7197886 0.80 CDK1 (0.41)
SCHEMBL72147 0.80 XDH (0.50) XDHPNPTK1BLMUSP2
SCHEMBL7037922 0.80 ALDH1A1 (0.36) HSD17B10MEN1KMT2AALDH1A1HPRT1
SCHEMBL28147771 0.78 ALDH1A1 (0.35) HSD17B10MEN1KMT2AALDH1A1HPRT1
SCHEMBL160199 0.76 GDA (0.37) PNPALDH1A1
SCHEMBL8820865 0.76 ADORA2A (0.46)
SCHEMBL1825531 0.75 XDH (0.51) XDHPNPTK1BLMUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 20071 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024138129-A2 ADENO-ASSOCIATED VIRUS FORMULATIONS SPARK THERAPEUTICS, INC. (US) 2024-06-27 WO claimed
CN-118222531-A Hypoxanthine-guanine phosphoribosyl transferase mutant and application thereof 浙江大学 2024-06-21 CN claimed
CN-112213491-B Kit for rapidly detecting drugs in hair and application of kit 自然资源部第三海洋研究所 2024-04-12 CN claimed
WO-2024074705-A1 CO-TREATMENT FOR GENE THERAPY Hansa Biopharma AB (SE) 2024-04-11 WO claimed
EP-4349365-A1 CO-TREATMENT FOR GENE THERAPY Hansa Biopharma AB (SE) 2024-04-10 EP claimed
CN-117836327-A Engineered chimeric fusion protein compositions and methods of use thereof 美洛德生物医药公司 2024-04-05 CN claimed
CN-117757867-A Method for synthesizing 5-phosphoribosyl by hypoxanthine-guanine phosphoribosyl transferase and application thereof 浙江大学 2024-03-26 CN claimed
CN-117720641-A Preparation method of drug-loaded human serum albumin combined monoclonal antibody 台州市耶大基因与细胞治疗研究院 2024-03-19 CN claimed
CN-114315715-B URAT1 inhibitor, and preparation method and application thereof 杭州中美华东制药有限公司 2024-02-20 CN claimed
CN-114315705-B URAT1 inhibitor, preparation method and application thereof 杭州中美华东制药有限公司 2024-02-20 CN claimed
EP-0285511-B1 IMMUNOASSAY OF THROMBOMODULIN MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 1992-11-25 EP claimed
US-5126253-A Production of monoclonal antibodies SUNTORY LIMITED (JP) 1992-06-30 US claimed
EP-0487611-A1 HERPES SIMPLEX VIRUS TYPE 1 MUTANT. BRITISH TECH GROUP (GB) 1992-06-03 EP claimed
EP-0114670-B1 NOVEL CELL LINES FOR USE IN THE PREPARATION OF HYBRIDOMA CELLS SUNTORY KABUSHIKI KAISHA, also known as SUNTORY LTD. (JP) 1991-10-02 EP claimed
WO-1991002788-A1 HERPES SIMPLEX VIRUS TYPE 1 MUTANT BRITISH TECHNOLOGY GROUP PLC (GB) 1991-03-07 WO claimed
EP-0286099-A2 Monoclonal antibodies reactive with endotoxin core VELOS GROUP (US) 1988-10-12 EP claimed
EP-0260829-A2 Antibodies reactive with chlorinated phenols and methods of preparing and using same WESTINGHOUSE ELECTRIC CORPORATION (US) 1988-03-23 EP claimed
EP-0258006-A2 Monoclonal antibodies reactive with chlorinated dibenzo-p-dioxins and method of preparing and using same WESTINGHOUSE ELECTRIC CORPORATION (US) 1988-03-02 EP claimed
EP-0183571-A2 Cosmid vectors BANYU SEIYAKU KABUSHIKI KAISHA (JP) 1986-06-04 EP claimed
EP-0114670-A2 Novel cell lines for use in the preparation of hybridoma cells SUNTORY KABUSHIKI KAISHA, also known as SUNTORY LTD. (JP) 1984-08-01 EP claimed