Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | PPARG | P37231 | 2/20 | 0.48 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.48 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9450326 | 0.91 | ALDH1A1 (0.44) | LTA4HAKR1B1ALDH1A1KDM4EPPARG | |
| SCHEMBL8379240 | 0.80 | SRPK1 (0.47) | ALDH1A1KDM4EPPARGNCOA2NCOA1 | |
| SCHEMBL7827157 | 0.79 | AKR1B1 (0.67) | AKR1B1KDM4EMAPTTDP1GAA | |
| SCHEMBL5023959 | 0.78 | LTA4H (0.66) | LTA4HALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL477614 | 0.78 | LTA4H (0.61) | LTA4HALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL5866028 | 0.78 | ALDH1A1 (0.43) | LTA4HAKR1B1ALDH1A1KDM4EPPARG | |
| SCHEMBL10367780 | 0.77 | TDP1 (0.43) | LTA4HAKR1B1ALDH1A1KDM4EPPARG | |
| SCHEMBL27407309 | 0.76 | S1PR1 (0.50) | ALDH1A1KDM4EPPARGNCOA2NCOA1 | |
| SCHEMBL27149766 | 0.76 | AKR1B1 (0.48) | AKR1B1KDM4EMAPTTDP1PTGER1 | |
| SCHEMBL9449867 | 0.76 | LTA4H (0.42) | LTA4HALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090209571-A1 | Phenanthrene derivatives as MPGES-1 inhibitors | CELLUMEN INC. | 2009-08-20 | — | — | US | disclosed |
| EP-2024371-A1 | PHENANTHRENE DERIVATIVES AS MPGES-1 INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007134434-A1 | PHENANTHRENE DERIVATIVES AS MPGES-1 INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2007-11-29 | — | — | WO | disclosed |
| EP-1471923-A4 | AMIDO MACROLIDES | KOSAN BIOSCIENCES INC (US) | 2006-01-11 | — | — | EP | disclosed |
| US-6939861-B2 | Amido macrolides | KOSAN BIOSCIENCES, INC. (US) | 2005-09-06 | — | — | US | disclosed |
| EP-1471923-A1 | AMIDO MACROLIDES | Kosan Biosciences, Inc. (US) | 2004-11-03 | — | — | EP | disclosed |
| US-20030199458-A1 | Amido macrolides | KOSAN BIOSCIENCES, INC. | 2003-10-23 | — | — | US | disclosed |
| WO-2003061671-A1 | AMIDO MACROLIDES | KOSAN BIOSCIENCES, INC. (US) | 2003-07-31 | — | — | WO | disclosed |
| US-4171366-A | 1-Naphthothienylalkyl-1H-imidazoles | CIBA-GEIGY CORPORATION (US) | 1979-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209571-A1 | Phenanthrene derivatives as MPGES-1 inhibitors | PTGES, PTGS1, PTGES2 | LTA4H 217/4885AKR1B1 350/4885ALDH1A1 158/4885 |
| US-20030199458-A1 | Amido macrolides | PCSK9, ABCB4, PCSK7 | LTA4H 244/4885AKR1B1 1858/4885ALDH1A1 4518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.