Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | BLM | P54132 | 2/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3837798 | 0.96 | KMT2A (0.50) | KMT2AKDM4EALDH1A1LMNACYP2C9 | |
| SCHEMBL4515554 | 0.88 | LMNA (0.51) | KMT2AKDM4EALDH1A1LMNACYP2C9 | |
| SCHEMBL4516519 | 0.84 | LMNA (0.48) | KMT2AKDM4EALDH1A1LMNACYP2C9 | |
| SCHEMBL3838240 | 0.74 | DGAT1 (0.33) | KMT2AKDM4EALDH1A1LMNACYP2C9 | |
| SCHEMBL3842579 | 0.74 | KMT2A (0.36) | KMT2AKDM4EALDH1A1LMNACYP2C9 | |
| SCHEMBL3842824 | 0.73 | SLC6A1 (0.57) | KMT2AKDM4EALDH1A1LMNACYP2C9 | |
| SCHEMBL3862550 | 0.72 | SLC6A1 (0.53) | KMT2AKDM4EALDH1A1LMNACYP2C9 | |
| SCHEMBL3842597 | 0.72 | DUT (0.34) | — | |
| SCHEMBL3841814 | 0.71 | SLC6A1 (0.56) | KMT2AKDM4EALDH1A1LMNACYP2C9 | |
| SCHEMBL9562561 | 0.71 | SLC6A1 (0.51) | KMT2AKDM4EALDH1A1LMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931341-B1 | 1H-INDOLE-PYRIDINECARBOXAMIDE AND 1H-INDOLE-PIPERIDINECARBOXAMIDE DERIVATIVES AND THEIR USE AS TYROSINE HYDROXYLASE INDUCERS | SERVIER LAB (FR) | 2009-11-04 | — | — | EP | disclosed |