Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.40 |
| ▸ | MLNR | O43193 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3846304 | 0.99 | HTR2C (0.42) | HTR2CHTR2BKDM2BPARP10PARP14 | |
| SCHEMBL5128971 | 0.89 | MTNR1A (0.42) | KDM2BALDH1A1MAPK1 | |
| SCHEMBL3846301 | 0.89 | SCN9A (0.41) | KDM2BPARP10HRH3ALDH1A1MAPK1 | |
| SCHEMBL3862104 | 0.89 | SCN9A (0.41) | KDM2BPARP10HRH3ALDH1A1MAPK1 | |
| SCHEMBL3841290 | 0.88 | ALDH1A1 (0.47) | KDM2BKCNH2SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL3843530 | 0.87 | FFAR1 (0.46) | HTR2CHTR2BKDM2BALDH1A1MAPK1 | |
| Hydrochloric Acid SCHEMBL3860311 | 0.87 | ALDH1A1 (0.47) | KDM2BKCNH2SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL3844103 | 0.85 | BTK (0.39) | HRH3SLC6A4BTKSCN9A | |
| SCHEMBL3844268 | 0.83 | POLB (0.42) | KDM2BALDH1A1MAPK1 | |
| SCHEMBL3881602 | 0.83 | MEN1 (0.43) | KDM2BALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027086-A2 | N-BENZOYL-AND N-BENZYLPYRROLIDIN-3-YLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth (US) | 2009-02-25 | — | — | EP | claimed |
| WO-2007136668-A2 | N-BENZOYL-AND N-BENZYLPYRROLIDIN-3-YLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2007-11-29 | — | — | WO | claimed |