Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 3/20 | 0.41 |
| ▸ | MMP9 | P14780 | 3/20 | 0.41 |
| ▸ | MMP13 | P45452 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5128971 | 0.92 | MTNR1A (0.42) | KDM2BMAPK1ALDH1A1 | |
| SCHEMBL3881602 | 0.91 | MEN1 (0.43) | KDM2BKMT2AKDM4EMEN1MAPT | |
| SCHEMBL3841290 | 0.90 | ALDH1A1 (0.47) | KDM2BMMP13NPC1RAB9AMAPK1 | |
| SCHEMBL3862104 | 0.89 | SCN9A (0.41) | KDM2BMAPK1LMNAALDH1A1 | |
| SCHEMBL3839546 | 0.89 | KDM4E (0.41) | KMT2AKDM4EMEN1MAPTTDP1 | |
| SCHEMBL3846301 | 0.89 | SCN9A (0.41) | KDM2BMAPK1LMNAALDH1A1 | |
| Hydrochloric Acid SCHEMBL3860311 | 0.89 | ALDH1A1 (0.47) | KDM2BMMP13NPC1RAB9AMAPK1 | |
| SCHEMBL3843530 | 0.86 | FFAR1 (0.46) | KDM2BMAPK1LMNAFFAR1ALDH1A1 | |
| SCHEMBL5133016 | 0.84 | FFAR1 (0.45) | MAPK1LMNAFFAR1ALDH1A1 | |
| SCHEMBL3846304 | 0.83 | HTR2C (0.42) | KDM2BMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027086-A2 | N-BENZOYL-AND N-BENZYLPYRROLIDIN-3-YLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth (US) | 2009-02-25 | — | — | EP | claimed |
| WO-2007136668-A2 | N-BENZOYL-AND N-BENZYLPYRROLIDIN-3-YLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2007-11-29 | — | — | WO | claimed |
| WO-2007136668-A9 | N-BENZOYL-AND N-BENZYLPYRROLIDIN-3-YLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH CORP (US) | 2008-03-27 | — | — | WO | disclosed |