Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 5/20 | 0.41 |
| ▸ | FPR2 | P25090 | 3/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3862104 | 1.00 | SCN9A (0.41) | SCN9AFPR2KDM2BPARP10HRH3 | |
| SCHEMBL3841290 | 0.90 | ALDH1A1 (0.47) | KDM2BALDH1A1LMNASMN1; SMN2MAPK1 | |
| SCHEMBL3846304 | 0.90 | HTR2C (0.42) | SCN9AKDM2BPARP10HRH3ALDH1A1 | |
| SCHEMBL3843546 | 0.89 | HTR2C (0.41) | SCN9AKDM2BPARP10HRH3ALDH1A1 | |
| SCHEMBL3844268 | 0.89 | POLB (0.42) | KDM2BALDH1A1LMNAMAPK1 | |
| SCHEMBL3839546 | 0.89 | KDM4E (0.41) | ALDH1A1MAPK1 | |
| SCHEMBL3881602 | 0.89 | MEN1 (0.43) | KDM2BALDH1A1LMNAMAPK1 | |
| Hydrochloric Acid SCHEMBL3860311 | 0.89 | ALDH1A1 (0.47) | KDM2BALDH1A1LMNASMN1; SMN2MAPK1 | |
| SCHEMBL3844103 | 0.87 | BTK (0.39) | SCN9AFPR2HRH3SMN1; SMN2 | |
| SCHEMBL5133016 | 0.84 | FFAR1 (0.45) | ALDH1A1LMNAMAPK1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027086-A2 | N-BENZOYL-AND N-BENZYLPYRROLIDIN-3-YLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth (US) | 2009-02-25 | — | — | EP | claimed |
| WO-2007136668-A2 | N-BENZOYL-AND N-BENZYLPYRROLIDIN-3-YLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2007-11-29 | — | — | WO | claimed |