Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | HTR2B | P41595 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | EED | O75530 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19066025 | 0.84 | MAOA (0.44) | HTR2CADRB1HTR6HTR2AHTR2B | |
| SCHEMBL14833444 | 0.81 | HTR2C (0.45) | HTR2CADRB1CHRNA7HTR2AHTR2B | |
| SCHEMBL2336871 | 0.81 | RIPK1 (0.40) | HTR2CHTR6HTR2AHTR2B | |
| SCHEMBL28168305 | 0.80 | DRD2 (0.48) | HTR2CCHRNA7DRD2 | |
| SCHEMBL14831356 | 0.79 | HTR2C (0.42) | HTR2CADRB1HTR2AHTR2B | |
| SCHEMBL5553500 | 0.79 | HTR2C (0.42) | HTR2CADRB1HTR2AHTR2B | |
| SCHEMBL14833446 | 0.79 | HTR2C (0.47) | HTR2CADRB1CHRNA7HTR2AHTR2B | |
| Hydrochloric Acid SCHEMBL15173335 | 0.78 | HTR2C (0.41) | HTR2CHTR2AHTR2B | |
| SCHEMBL29200484 | 0.77 | SLC6A4 (0.42) | HTR2CHTR2AHTR2BDRD2 | |
| SCHEMBL27603668 | 0.72 | ALDH1A1 (0.45) | CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |