Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 8/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | AKT2 | P31751 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3849706 | 0.91 | FLT3 (0.46) | FYNRIPK2CLK1DYRK1AFLT3 | |
| SCHEMBL3845403 | 0.89 | TGFBR1 (0.40) | FYNRIPK2CLK1DYRK1AMEN1 | |
| SCHEMBL3850019 | 0.88 | L3MBTL1 (0.41) | FYNRIPK2CLK1DYRK1AMEN1 | |
| SCHEMBL3846734 | 0.88 | MKNK1 (0.44) | FYNMKNK1MKNK2FLT3AKT1 | |
| SCHEMBL3849352 | 0.86 | L3MBTL1 (0.42) | FYNRIPK2CLK1DYRK1AMEN1 | |
| SCHEMBL3854300 | 0.85 | CLK1 (0.37) | FYNRIPK2CLK1DYRK1AMEN1 | |
| SCHEMBL3852272 | 0.83 | TGFBR1 (0.41) | FYNMKNK1MKNK2MAPT | |
| SCHEMBL3848151 | 0.80 | ALDH1A1 (0.38) | TP53MAPT | |
| SCHEMBL3846497 | 0.79 | FYN (0.41) | FYNMAPTFLT3 | |
| SCHEMBL3854652 | 0.78 | GABRA1 (0.37) | FYNCLK1DYRK1AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |