Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 4/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | TYK2 | P29597 | 3/20 | 0.39 |
| ▸ | JAK3 | P52333 | 3/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TPH1 | P17752 | 1/20 | 0.38 |
| ▸ | TPH2 | Q8IWU9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4439862 | 0.91 | POLB (0.43) | POLBEGFRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4441079 | 0.78 | SMN1; SMN2 (0.42) | POLBEGFRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4733245 | 0.76 | NPSR1 (0.46) | EGFRNPC1RAB9ASMN1; SMN2EGLN1 | |
| SCHEMBL3357330 | 0.76 | KCNH2 (0.66) | KCNH2 | |
| SCHEMBL3838947 | 0.72 | MPO (0.40) | EGFRKCNH2 | |
| SCHEMBL5048771 | 0.71 | KCNH2 (0.46) | EGFRKCNH2TPH1TPH2 | |
| SCHEMBL5047886 | 0.71 | SIGMAR1 (0.38) | KCNH2 | |
| SCHEMBL5047682 | 0.70 | CCR3 (0.41) | — | |
| SCHEMBL16487837 | 0.69 | CYP1A2 (0.51) | POLBEGFRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4444391 | 0.68 | TP53 (0.40) | SMN1; SMN2KCNH2KDM4EALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001126-A1 | SUBSTITUTED PIPERIDINE DERIVATIVES AND THEIR USE AS ANTIBATERIAL AGENTS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |