Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 8/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5047886 | 0.88 | SIGMAR1 (0.38) | DYRK1ACXCR3SIGMAR1DRD4 | |
| SCHEMBL5048771 | 0.80 | KCNH2 (0.46) | — | |
| SCHEMBL3838947 | 0.73 | MPO (0.40) | CCR3LMNATSHR | |
| SCHEMBL3847249 | 0.71 | HRH4 (0.42) | DRD4 | |
| SCHEMBL3847577 | 0.70 | SLC40A1 (0.39) | LMNA | |
| SCHEMBL921167 | 0.70 | KCNH2 (0.46) | L3MBTL1GLATSHR | |
| SCHEMBL6079889 | 0.70 | KCNH2 (0.47) | DYRK1AL3MBTL1SIGMAR1 | |
| SCHEMBL4758202 | 0.70 | POLB (0.43) | — | |
| SCHEMBL921593 | 0.69 | CNR2 (0.46) | CCR3MCHR1 | |
| SCHEMBL6080763 | 0.69 | CNR2 (0.44) | DYRK1ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893599-A1 | COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006134378-A1 | COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | WO | disclosed |