Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | NPY1R | P25929 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPY2R | P49146 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4462942 | 0.83 | FADS1 (0.49) | LMNAMAPTRAB9ANPC1MEN1 | |
| SCHEMBL3855951 | 0.82 | NPSR1 (0.48) | NPSR1LMNAMAPTPOLBRAB9A | |
| SCHEMBL2301152 | 0.81 | RAF1 (0.57) | NPSR1LMNAMAPTPOLBRAB9A | |
| SCHEMBL4464511 | 0.80 | MAPT (0.44) | NPSR1LMNAMAPTRAB9AKDM4E | |
| SCHEMBL4473204 | 0.80 | NPC1 (0.41) | NPSR1LMNAMAPTRAB9ANPC1 | |
| SCHEMBL3848659 | 0.79 | MEN1 (0.52) | NPSR1LMNAMAPTRAB9AKDM4E | |
| SCHEMBL3850936 | 0.78 | GPR35 (0.43) | NPSR1MAPTRAB9AKDM4ENPC1 | |
| SCHEMBL1467642 | 0.78 | NPSR1 (0.46) | NPSR1LMNAMAPTPOLBRAB9A | |
| SCHEMBL4459109 | 0.77 | RAF1 (0.41) | NPSR1LMNAMAPTPOLBKDM4E | |
| SCHEMBL4470605 | 0.77 | NPC1 (0.40) | NPSR1MAPTPOLBRAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-A1 | METHODS OF USING MEK INHIBITORS | Exelixis, Inc. (US) | 2009-09-23 | — | — | EP | claimed |
| WO-2008076415-A1 | METHODS OF USING MEK INHIBITORS | EXELIXIS, INC. (US) | 2008-06-26 | — | — | WO | claimed |
| EP-2101759-B1 | METHODS OF USING MEK INHIBITORS | EXELIXIS INC (US) | 2018-10-10 | — | — | EP | disclosed |