Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | RAF1 | P04049 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3850936 | 0.88 | GPR35 (0.43) | NPSR1NR1H4PPARGRAB9AKMT2A | |
| SCHEMBL27774235 | 0.86 | PPARG (0.39) | NR1H4PPARGKMT2ARAF1BRAF | |
| SCHEMBL4470605 | 0.84 | NPC1 (0.40) | NPSR1NR1H4PPARGTDP1RAB9A | |
| SCHEMBL4464511 | 0.84 | MAPT (0.44) | NPSR1NR1H4PPARGTDP1RAB9A | |
| SCHEMBL3848659 | 0.83 | MEN1 (0.52) | NPSR1TDP1RAB9ALMNAKMT2A | |
| SCHEMBL3848804 | 0.82 | NPSR1 (0.48) | NPSR1NR1H4PPARGTDP1RAB9A | |
| SCHEMBL2300130 | 0.81 | RAF1 (0.57) | NPSR1RAB9ALMNAKMT2AKDR | |
| SCHEMBL3848177 | 0.80 | MAPT (0.44) | NPSR1NR1H4PPARGTDP1RAB9A | |
| SCHEMBL4473204 | 0.80 | NPC1 (0.41) | NPSR1NR1H4PPARGRAB9ALMNA | |
| SCHEMBL3857514 | 0.79 | RAF1 (0.38) | NPSR1NR1H4PPARGRAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-A1 | METHODS OF USING MEK INHIBITORS | Exelixis, Inc. (US) | 2009-09-23 | — | — | EP | claimed |
| WO-2008076415-A1 | METHODS OF USING MEK INHIBITORS | EXELIXIS, INC. (US) | 2008-06-26 | — | — | WO | claimed |