Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | RAF1 | P04049 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3856725 | 0.88 | RAF1 (0.37) | NPC1RAB9ARAF1BRAFCYP2C19 | |
| SCHEMBL3857514 | 0.87 | RAF1 (0.38) | NPC1RAB9ARAF1BRAFCYP2C19 | |
| SCHEMBL4469804 | 0.81 | HTT (0.46) | NPC1RAB9ARAF1BRAFCYP2C19 | |
| SCHEMBL4462942 | 0.81 | FADS1 (0.49) | NPC1RAB9AMAPTLMNAKMT2A | |
| SCHEMBL3855951 | 0.80 | NPSR1 (0.48) | NPC1RAB9ARAF1BRAFCYP2C19 | |
| SCHEMBL3850936 | 0.80 | GPR35 (0.43) | NPC1RAB9ARAF1BRAFCYP2C19 | |
| SCHEMBL4470605 | 0.80 | NPC1 (0.40) | NPC1RAB9ARAF1BRAFCYP2C19 | |
| SCHEMBL3848804 | 0.80 | NPSR1 (0.48) | NPC1RAB9AHPGDMAPTNPSR1 | |
| SCHEMBL2296483 | 0.80 | RAF1 (0.56) | NPC1RAB9ARAF1BRAFCYP2C19 | |
| SCHEMBL4459109 | 0.79 | RAF1 (0.41) | RAF1BRAFCYP2C19CYP1A2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |