Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3855951 | 0.88 | NPSR1 (0.48) | MAPTNR1H4PPARGCYP2C9CYP2C19 | |
| SCHEMBL4470605 | 0.88 | NPC1 (0.40) | GPR35MAPTNR1H4PPARGCYP2C9 | |
| SCHEMBL27774235 | 0.86 | PPARG (0.39) | MAPTNR1H4PPARGCYP2C9CYP2C19 | |
| SCHEMBL3848177 | 0.84 | MAPT (0.44) | MAPTNR1H4PPARGCYP2C9CYP2C19 | |
| SCHEMBL4473204 | 0.80 | NPC1 (0.41) | MAPTNR1H4PPARGCYP2C9CYP2C19 | |
| SCHEMBL4464511 | 0.80 | MAPT (0.44) | MAPTNR1H4PPARGCYP2C9CYP2C19 | |
| SCHEMBL2297867 | 0.80 | RAF1 (0.54) | MAPTCYP2C9CYP2C19KMT2ATP53 | |
| SCHEMBL3857514 | 0.79 | RAF1 (0.38) | MAPTNR1H4PPARGCYP2C9CYP2C19 | |
| SCHEMBL4469804 | 0.79 | HTT (0.46) | MAPTCYP2C9CYP2C19KMT2ANPC1 | |
| SCHEMBL3848804 | 0.78 | NPSR1 (0.48) | MAPTNR1H4PPARGKMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-A1 | METHODS OF USING MEK INHIBITORS | Exelixis, Inc. (US) | 2009-09-23 | — | — | EP | claimed |
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |
| WO-2008076415-A1 | METHODS OF USING MEK INHIBITORS | EXELIXIS, INC. (US) | 2008-06-26 | — | — | WO | claimed |