Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.70 |
| ▸ | GLA | P06280 | 1/20 | 0.70 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | ATF1 | P18846 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.44 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.44 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.43 |
| ▸ | SORT1 | Q99523 | 5/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3849262 | 0.80 | RAB9A (0.57) | ALDH1A1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL18420793 | 0.73 | SMN1; SMN2 (0.66) | ALDH1A1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL29803616 | 0.72 | NPC1 (0.65) | ALDH1A1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL24670566 | 0.72 | NPC1 (0.65) | ALDH1A1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL31511667 | 0.72 | NPC1 (0.59) | ALDH1A1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL1648482 | 0.72 | DGAT1 (0.59) | ALDH1A1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL13485811 | 0.71 | DGAT1 (0.63) | ALDH1A1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL27007857 | 0.71 | DGAT1 (0.63) | ALDH1A1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL3345916 | 0.71 | DGAT1 (0.54) | ALDH1A1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL3845645 | 0.71 | SORT1 (0.73) | ALDH1A1SMN1; SMN2GLANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |