Sugi Predict

Sugi Predict / Compounds / SCHEMBL384996

SCHEMBL384996

SCHEMBL384996

OB(O)c1ccc(Br)cc1F

nearest known ligand 0.59

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ DGAT1 O75907 1/20 0.44
▸ CA1 P00915 1/20 0.41
▸ CA2 P00918 1/20 0.41
▸ TSHR P16473 1/20 0.41
▸ KDM1A O60341 2/20 0.37
▸ KDM1B Q8NB78 1/20 0.37
▸ LMNA P02545 4/20 0.36
▸ NPC1 O15118 5/20 0.35
▸ RAB9A P51151 5/20 0.35
▸ SMN1; SMN2 Q16637 3/20 0.35
▸ ALDH1A1 P00352 3/20 0.35
▸ ALOX12 P18054 2/20 0.35
▸ TP53 P04637 1/20 0.35
▸ HPGD P15428 1/20 0.35
▸ PYCR1 P32322 1/20 0.35
▸ ALOX15 P16050 1/20 0.34
▸ GAA P10253 1/20 0.34
▸ KMT2A Q03164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30384882 1.00 DGAT1 (0.44) DGAT1CA1CA2TSHRKDM1A
SCHEMBL15868559 0.85 CA1 (0.41) CA1CA2TSHRLMNAALDH1A1
SCHEMBL1529185 0.82 CA1 (0.41) DGAT1CA1CA2TSHRKDM1A
SCHEMBL8715929 0.78 TSHR (0.46) CA1CA2TSHRLMNASMN1; SMN2
SCHEMBL26741447 0.78 DGAT1 (0.42) DGAT1KDM1AKDM1BLMNANPC1
SCHEMBL39406 0.76 CES2 (0.43) ALDH1A1ALOX12KMT2A
SCHEMBL29395656 0.76 CES2 (0.43) ALDH1A1ALOX12KMT2A
SCHEMBL29650713 0.76 ALOX15 (0.48) CA1CA2TSHRLMNASMN1; SMN2
SCHEMBL12384874 0.76 ESR2 (0.36) LMNA
SCHEMBL16049999 0.76 ALOX15 (0.48) CA1CA2TSHRLMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 156 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105085190-B Preparing method of 2,6-difluoro-4-bromophenol 中节能万润股份有限公司 2017-01-25 — — CN claimed
CN-105085190-A Preparing method of 2,6-difluoro-4-bromophenol CECEP VALIANT CO LTD 2015-11-25 — — CN claimed
US-12595230-B2 Substituted 6,7-dihydro-5H-benzo[7]annulene compounds and their derivatives, processes for their preparation and therapeutic uses thereof SANOFI (FR) 2026-04-07 — — US disclosed
EP-4712969-A1 CYCLIN INHIBITORS Circle Pharma, Inc. (US) 2026-03-25 — — EP disclosed
CN-120004843-A Xanthene fused ring compound for organic luminescent material and application thereof 西安瑞联新材料股份有限公司 2025-05-16 — — CN disclosed
EP-4506344-A1 1,4-DIHETEROCYCLIC SUBSTITUTED AROMATIC RING OR AROMATIC HETEROCYCLIC COMPOUND AND USE THEREOF Bebetter Med Inc. (CN) 2025-02-12 — — EP disclosed
US-20250034116-A1 1,4-DIHETEROCYCLIC SUBSTITUTED AROMATIC RING OR AROMATIC HETEROCYCLIC COMPOUND AND USE THEREOF BEBETTER MED INC. (CN) 2025-01-30 — — US disclosed
US-20240408169-A1 CYCLIN INHIBITORS CIRCLE PHARMA, INC. 2024-12-12 — — US disclosed
CN-118852191-A Compound taking fluoranthene double five-membered ring as parent nucleus and application thereof 西安瑞联新材料股份有限公司 2024-10-29 — — CN disclosed
EP-3860994-B1 TRANSCRIPTION FACTOR BRN2 INHIBITORY COMPOUNDS AS THERAPEUTICS AND METHODS FOR THEIR USE UNIV BRITISH COLUMBIA (CA) 2024-08-14 — — EP disclosed
EP-4228758-B1 SUBSTITUTED 6,7-DIHYDRO-5H-BENZO[7]ANNULENE COMPOUNDS AND THEIR DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC USES THEREOF SANOFI SA (FR) 2024-07-24 — — EP disclosed
US-6900227-B2 Benzodioxole derivatives HOFFMANN-LA ROCHE INC. (US) 2005-05-31 — — US disclosed
EP-1532132-A1 NOVEL BENZODIOXOLES F.HOFFMANN-LA ROCHE AG (CH) 2005-05-25 — — EP disclosed
US-20050059722-A1 Substituted indazoles, compositions containing them, method of production and use AVENTIS PHARMA S.A. (FR) 2005-03-17 — — US disclosed
US-6858638-B2 Substituted indazoles, compositions containing them, method of production and use AVENTIS PHARMA S.A. (FR) 2005-02-22 — — US disclosed
WO-2004101568-A1 DIAMINOPYRROLOQUINAZOLINES COMPOUNDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2004-11-25 — — WO disclosed
US-20040235872-A1 Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors BERTHEL STEVEN JOSEPH (US) 2004-11-25 — — US disclosed
US-20040142922-A1 Benzodioxole derivatives HOFFMANN-LA ROCHE INC. 2004-07-22 — — US disclosed
WO-2004041833-A1 HALO SULFONYL ARYL BORONATES NOVO NORDISK A/S (DK) 2004-05-21 — — WO disclosed
WO-2004013120-A1 NOVEL BENZODIOXOLES F. HOFFMANN-LA ROCHE AG (CH) 2004-02-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040235872-A1 Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors PTPN5, PPP5C, PTP4A2 DGAT1 1698/4885CA1 4457/4885CA2 2569/4885
US-20240408169-A1 CYCLIN INHIBITORS CCNI, CDK2, CDK1 DGAT1 3002/4885CA1 3745/4885CA2 4168/4885
US-20050059722-A1 Substituted indazoles, compositions containing them, method of production and use ABL1, CDK3, CILK1 DGAT1 2673/4885CA1 4252/4885CA2 3035/4885
US-12595230-B2 Substituted 6,7-dihydro-5H-benzo[7]annulene compounds and their derivatives, processes for their preparation and therapeutic uses thereof FSHR, CYP19A1, GPER1 DGAT1 3311/4885CA1 716/4885CA2 1304/4885
US-20040142922-A1 Benzodioxole derivatives CNR1, CNR2, GPR119 DGAT1 230/4885CA1 3482/4885CA2 2070/4885
US-20250034116-A1 1,4-DIHETEROCYCLIC SUBSTITUTED AROMATIC RING OR AROMATIC HETEROCYCLIC COMPOUND AND USE THEREOF CYP46A1, CYP4A22, CYP2C19 DGAT1 285/4885CA1 4497/4885CA2 4431/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.