Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 11/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | FAAH | O00519 | 6/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL675612 | 0.78 | NAAA (0.64) | NAAAFAAH | |
| SCHEMBL13881704 | 0.76 | NAAA (0.49) | NAAAPIK3CDFAAH | |
| SCHEMBL7694428 | 0.71 | NAAA (0.51) | NAAAPIK3CDFAAH | |
| SCHEMBL9586348 | 0.71 | NAAA (0.51) | NAAAFAAH | |
| SCHEMBL12999946 | 0.71 | NAAA (0.75) | NAAAFAAH | |
| SCHEMBL29033889 | 0.71 | NAAA (0.61) | NAAAFAAH | |
| SCHEMBL1027659 | 0.70 | — | — | |
| SCHEMBL24489812 | 0.69 | NAAA (0.46) | NAAAPIK3CDFAAH | |
| SCHEMBL7569177 | 0.69 | NAAA (0.48) | NAAAFAAH | |
| SCHEMBL3130166 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412323-B1 | PROTECTED 3,5-DIHYDROXY-2,2-DIMETHYL-VALERONITRILES FOR THE SYNTHESIS OF EPOTHILONES AND DERIVATIVES AND METHOD FOR THE PRODUCTION AND USE THEREOF | BAYER SCHERING PHARMA AG (DE) | 2009-09-30 | — | — | EP | disclosed |
| US-20080161580-A1 | PROTECTED 3,5-DIHYDROXY-2,2-DIMETHYL-VALEROAMIDES FOR THE SYNTHESIS OF EPOTHILONES AND DERIVATIVES AND PROCESS FOR THE PRODUCTION AND THE USE | WESTERMANN JURGEN | 2008-07-03 | — | — | US | disclosed |
| US-7368568-B2 | Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for production and the use | BAYER SCHERING PHARMA AG (DE) | 2008-05-06 | — | — | US | disclosed |
| US-7358382-B2 | Protected 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production | BAYER SCHERING PHARMA AG (DE) | 2008-04-15 | — | — | US | disclosed |
| US-7034165-B2 | Protected 3,-5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production | SCHERING AG (DE) | 2006-04-25 | — | — | US | disclosed |
| US-20050272731-A1 | Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for production and the use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2005-12-08 | — | — | US | disclosed |
| US-20050267306-A1 | Protected 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2005-12-01 | — | — | US | disclosed |
| US-6933385-B2 | Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use | SCHERING AG (DE) | 2005-08-23 | — | — | US | disclosed |
| EP-1412323-A1 | PROTECTED 3,5-DIHYDROXY-2,2-DIMETHYL-VALERONITRILES FOR THE SYNTHESIS OF EPOTHILONES AND DERIVATIVES AND METHOD FOR THE PRODUCTION AND USE THEREOF | Schering Aktiengesellschaft (DE) | 2004-04-28 | — | — | EP | disclosed |
| EP-1412322-A2 | PROTECTED 3.5-DIHYDROXY-2.2-DIMETHYL-VALEROAMIDES FOR THE SYNTHESIS OF EPOTHILONE AND DERIVATIVES AND METHOD FOR THE PRODUCTION AND USE THEREOF | Schering Aktiengesellschaft (DE) | 2004-04-28 | — | — | EP | disclosed |
| US-20030158412-A1 | Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-08-21 | — | — | US | disclosed |
| US-20030149281-A1 | Protected 3,-5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production | SCHERING AG (DE) | 2003-08-07 | — | — | US | disclosed |
| WO-2003014068-A1 | PROTECTED 3.5-DIHYDROXY-2.2-DIMETHYL-VALERONITRILES FOR THE SYNTHESIS OF EPOTHILONES AND DERIVATIVES AND METHOD FOR THE PRODUCTION AND USE THEREOF | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-02-20 | — | — | WO | disclosed |
| WO-2003014063-A2 | PROTECTED 3.5-DIHYDROXY-2.2-DIMETHYL-VALEROAMIDES FOR THE SYNTHESIS OF EPOTHILONE AND DERIVATIVES AND METHOD FOR THE PRODUCTION AND USE THEREOF | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-02-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161580-A1 | PROTECTED 3,5-DIHYDROXY-2,2-DIMETHYL-VALEROAMIDES FOR THE SYNTHESIS OF EPOTHILONES AND DERIVATIVES AND PROCESS FOR THE PRODUCTION AND THE USE | DHPS, VARS1, CYP51A1 | NAAA 1247/4885PIK3CD 1942/4885FAAH 1569/4885 |
| US-20050267306-A1 | Protected 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production | DHPS, VARS1, CYP51A1 | NAAA 3459/4885PIK3CD 1484/4885FAAH 3718/4885 |
| US-20030158412-A1 | Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use | DHPS, VARS1, CYP51A1 | NAAA 1247/4885PIK3CD 1942/4885FAAH 1569/4885 |
| US-20050272731-A1 | Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for production and the use | DHPS, VARS1, HSD17B12 | NAAA 2061/4885PIK3CD 2949/4885FAAH 3063/4885 |
| US-20030149281-A1 | Protected 3,-5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production | DHPS, VARS1, CYP51A1 | NAAA 3483/4885PIK3CD 1427/4885FAAH 3725/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.