Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.41 |
| ▸ | ESR1 | P03372 | 6/20 | 0.41 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3857040 | 0.87 | PPARG (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3853909 | 0.86 | SIRT2 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3853510 | 0.86 | PLA2G2A (0.48) | PLA2G2AMAPTNPSR1 | |
| SCHEMBL3858272 | 0.85 | ESR1 (0.51) | ESR1 | |
| SCHEMBL3852177 | 0.85 | PPARG (0.55) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4197170 | 0.84 | PSEN1 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3854992 | 0.83 | PLA2G2A (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3853290 | 0.83 | ESR1 (0.40) | PLA2G2AESR1PLA2G4ASIRT2 | |
| SCHEMBL3856331 | 0.82 | PLA2G2A (0.49) | PLA2G2AESR1MAPTSIRT2PPARG | |
| SCHEMBL3853281 | 0.81 | PLA2G2A (0.50) | PLA2G2AADAM17POLBMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582773-B2 | Substituted phenyl indoles | WYETH (US) | 2009-09-01 | — | — | US | disclosed |
| US-20050070592-A1 | Substituted phenyl indoles | WYETH (US) | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070592-A1 | Substituted phenyl indoles | TPH2, IDO2, AANAT | PSEN1 2526/4885PSEN2 1065/4885APH1B 4237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.