Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 18/20 | 0.50 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3853126 | 0.88 | MAPT (0.48) | PLA2G2APLA2G1BPOLBMAPTNPSR1 | |
| SCHEMBL3853909 | 0.88 | SIRT2 (0.42) | PLA2G2APLA2G1BPOLBMAPTNPSR1 | |
| SCHEMBL3853485 | 0.87 | MEN1 (0.43) | PLA2G2APOLBMAPTNPSR1ADAM17 | |
| SCHEMBL3857137 | 0.85 | PLA2G2A (0.61) | PLA2G2APLA2G1BMAPTNPSR1 | |
| SCHEMBL3854541 | 0.83 | PLA2G2A (0.67) | PLA2G2APLA2G1B | |
| SCHEMBL3858272 | 0.82 | ESR1 (0.51) | — | |
| SCHEMBL3855935 | 0.81 | PLA2G2A (0.57) | PLA2G2APLA2G1B | |
| SCHEMBL3852236 | 0.81 | PSEN1 (0.46) | PLA2G2APOLBMAPTNPSR1ADAM17 | |
| SCHEMBL3854587 | 0.80 | PPARG (0.48) | — | |
| SCHEMBL3854952 | 0.80 | PLA2G2A (0.60) | PLA2G2APLA2G1BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582773-B2 | Substituted phenyl indoles | WYETH (US) | 2009-09-01 | — | — | US | disclosed |
| US-20050070592-A1 | Substituted phenyl indoles | WYETH (US) | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070592-A1 | Substituted phenyl indoles | TPH2, IDO2, AANAT | PLA2G2A 3821/4885PLA2G1B 3476/4885POLB 3914/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.