SCHEMBL3852963

SCHEMBL3852963

O=P(O)(O)OC(O)[C@H]1O[C@@H](n2cnc3c(Cl)ncnc32)[C@H](O)[C@@H]1O

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE4D Q08499 2/20 0.49
PDE4A P27815 1/20 0.49
PDE4B Q07343 1/20 0.49
PDE4C Q08493 1/20 0.49
PRMT5 O14744 4/20 0.48
WDR77 Q9BQA1 4/20 0.48
DNPH1 O43598 3/20 0.48
P2RY2 P41231 3/20 0.48
P2RY1 P47900 3/20 0.48
SRC P12931 2/20 0.48
PRKAB2 O43741 1/20 0.48
TRPM2 O94759 1/20 0.48
LDHA P00338 1/20 0.48
ADRB2 P07550 1/20 0.48
FBP1 P09467 1/20 0.48
ADORA1 P30542 1/20 0.48
PRKAG1 P54619 1/20 0.48
PRKAA2 P54646 1/20 0.48
KCNH2 Q12809 1/20 0.48
PRKAA1 Q13131 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4079343 0.88 DNPH1 (0.49) PDE4DPRMT5WDR77DNPH1P2RY2
SCHEMBL11526724 0.88 DNPH1 (0.49) PDE4DPRMT5WDR77DNPH1P2RY2
SCHEMBL756245 0.88 P2RY2 (0.64) PDE4DDNPH1P2RY2P2RY1SRC
Water SCHEMBL443839 0.87 P2RY2 (0.63) PDE4DDNPH1P2RY2P2RY1SRC
SCHEMBL11660862 0.83 NT5E (0.47) PDE4DDNPH1P2RY2P2RY1SRC
SCHEMBL11659485 0.82 NT5E (0.49) PDE4DDNPH1P2RY2P2RY1SRC
SCHEMBL11662632 0.82 ADK (0.47) PDE4DPRMT5WDR77DNPH1P2RY2
SCHEMBL10912591 0.81 PRMT5 (0.54) PDE4DPDE4APDE4BPDE4CPRMT5
SCHEMBL11568109 0.80 DNMT3B (0.47) PDE4DDNPH1P2RY2P2RY1SRC
SCHEMBL4830646 0.80 PRMT5 (0.51) PDE4DPDE4APDE4BPDE4CPRMT5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7579162-B2 Method of detection in homogeneous phase, especially of progesterone in mammals' milk, and corresponding kit CEVA SANTE ANIMALE (FR) 2009-08-25 US disclosed
EP-1915619-A2 METHOD FOR CARRYING OUT HOMOGENEOUS PHASE DETECTION, IN PARTICULAR, FOR DETECTING THE PROGESTERONE IN THE MILK OF A MAMMAL AND CORRESPONDING KIT CEVA SANTE ANIMALE (FR) 2008-04-30 EP disclosed
US-20070042449-A1 Method of detection in homogeneous phase, especially of progesterone in mammals' milk, and corresponding kit CEVA SANTE ANIMALE (FR) 2007-02-22 US disclosed
WO-2007020357-A2 METHOD FOR CARRYING OUT HOMOGENEOUS PHASE DETECTION, IN PARTICULAR, FOR DETECTING THE PROGESTERONE IN THE MILK OF A MAMMAL AND CORRESPONDING KIT CEVA SANTE ANIMALE (FR) 2007-02-22 WO disclosed