SCHEMBL3853121

SCHEMBL3853121

C=C[Si]([O])(C=C)c1ccccc1

nearest known ligand 0.38

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.38
TSHR P16473 2/20 0.38
AKT1 P31749 1/20 0.36
ALOX15 P16050 1/20 0.33
TGM2 P21980 1/20 0.32
CYP2A6 P11509 1/20 0.32
MAPT P10636 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
ESR1 P03372 1/20 0.30
ESR2 Q92731 1/20 0.30
ADH1B P00325 1/20 0.30
ADH1C P00326 1/20 0.30
ADH1A P07327 1/20 0.30
ADH7 P40394 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL465009 0.79 ALDH1A1 (0.38) ALDH1A1TSHRAKT1ALOX15TGM2
SCHEMBL1674781 0.78 ALDH1A1 (0.41) ALDH1A1TSHRAKT1ALOX15TGM2
SCHEMBL304128 0.75 MAPT (0.37) ALDH1A1TSHRAKT1ALOX15TGM2
SCHEMBL160241 0.72 ALDH1A1 (0.41) ALDH1A1TSHRAKT1ALOX15TGM2
SCHEMBL226240 0.72 ALDH1A1 (0.41) ALDH1A1TSHRAKT1ALOX15TGM2
SCHEMBL10795829 0.70 MAPT (0.34) ALDH1A1TSHRAKT1MAPT
SCHEMBL11024215 0.70 ALDH1A1 (0.36) ALDH1A1TSHRAKT1ALOX15TGM2
SCHEMBL1566053 0.69 ALDH1A1 (0.34) ALDH1A1TSHRAKT1ALOX15MAPT
SCHEMBL3321240 0.69 TSHR (0.33) ALDH1A1TSHRAKT1ALOX15ESR1
SCHEMBL11024218 0.69 AKT1 (0.41) ALDH1A1TSHRAKT1ALOX15TGM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11866583-B2 Addition-curable liquid silicone rubber composition and molded silicone-rubber object SHIN-ETSU CHEMICAL CO., LTD. (JP) 2024-01-09 US disclosed
EP-3808815-B1 ADDITION-CURABLE LIQUID SILICONE RUBBER COMPOSITION AND MOLDED SILICONE-RUBBER OBJECT SHINETSU CHEMICAL CO (JP) 2023-03-08 EP disclosed
CN-112154187-B Addition-curable liquid silicone rubber composition and silicone rubber molded body 信越化学工业株式会社 2022-12-09 CN disclosed
US-20210292556-A1 ADDITION-CURABLE LIQUID SILICONE RUBBER COMPOSITION AND MOLDED SILICONE-RUBBER OBJECT SHIN-ETSU CHEMICAL CO., LTD. (JP) 2021-09-23 US disclosed
EP-3808815-A1 ADDITION-CURABLE LIQUID SILICONE RUBBER COMPOSITION AND MOLDED SILICONE-RUBBER OBJECT Shin-Etsu Chemical Co., Ltd. (JP) 2021-04-21 EP disclosed
CN-112154187-A Addition-curable liquid silicone rubber composition and silicone rubber molded body 信越化学工业株式会社 2020-12-29 CN disclosed
EP-1551905-B1 SILICONE RESINS DOW CORNING (US) 2009-08-19 EP disclosed
US-7425351-B2 Silicone resins DOW CORNING CORPORATION (US) 2008-09-16 US disclosed
US-20060057297-A1 Silicone resins DOW CORNING S.A. (BE) 2006-03-16 US disclosed
EP-1551905-A1 SILICONE RESINS Dow Corning Corporation (US) 2005-07-13 EP disclosed
WO-2004035661-A1 SILICONE RESINS DOW CORNING CORPORATION (US) 2004-04-29 WO disclosed