SCHEMBL304128

SCHEMBL304128

C=C[Si](C)([O])c1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.37
ESR1 P03372 1/20 0.37
ESR2 Q92731 1/20 0.37
ALDH1A1 P00352 7/20 0.36
TSHR P16473 4/20 0.35
CYP2A6 P11509 1/20 0.35
AKT1 P31749 1/20 0.33
ADH1B P00325 1/20 0.32
ADH1C P00326 1/20 0.32
ADH1A P07327 1/20 0.32
ADH7 P40394 1/20 0.32
MEN1 O00255 2/20 0.31
KMT2A Q03164 2/20 0.31
TAAR1 Q96RJ0 1/20 0.31
ALOX15 P16050 1/20 0.31
HDAC8 Q9BY41 1/20 0.31
LMNA P02545 2/20 0.31
TDP1 Q9NUW8 2/20 0.31
THRB P10828 1/20 0.31
BLM P54132 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL160355 0.75 ESR1 (0.39) MAPTESR1ESR2ALDH1A1TSHR
SCHEMBL3853121 0.75 ALDH1A1 (0.38) MAPTESR1ESR2ALDH1A1TSHR
SCHEMBL2524118 0.75 ESR1 (0.39) MAPTESR1ESR2ALDH1A1TSHR
SCHEMBL465009 0.75 ALDH1A1 (0.38) MAPTESR1ESR2ALDH1A1TSHR
SCHEMBL453982 0.75 NR1H2 (0.48) MAPTESR1ESR2ALDH1A1TSHR
SCHEMBL7093586 0.74 MAPT (0.40) MAPTESR1ESR2ALDH1A1TSHR
SCHEMBL8040579 0.73 ESR1 (0.43) MAPTESR1ESR2ALDH1A1TSHR
SCHEMBL10546488 0.71 ESR1 (0.37) MAPTESR1ESR2ALDH1A1TSHR
SCHEMBL4530855 0.71 NR1H2 (0.46) MAPTESR1ESR2ALDH1A1TSHR
SCHEMBL296774 0.71 ESR1 (0.37) MAPTESR1ESR2ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 716 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9481851-B2 Thermally-curable heat-conductive silicone grease composition SHIN-ETSU CHEMICAL CO., LTD. (JP) 2016-11-01 US claimed
US-7781560-B2 Curable mixture of an alkoxyalkyl endcapped polysiloxane prepared by reacting a vinyl-terminated polysiloxane with a mono- or disiloxyalkyldisiloxane, an alkylhydrogenpolysiloxane, and organosilicon compound, and a hydrosilation catalyst; has good adhesion to unclean aluminum die castings DOW CORNING TORAY COMPANY, LTD. (JP) 2010-08-24 US claimed
EP-1235542-B1 SILICONE ELASTOMER MATERIAL FOR USE WITH ENTERIC FEEDING DEVICE KIMBERLY CLARK CO (US) 2009-03-04 EP claimed
US-6991887-B1 Photopatternable sorbent and functionalized films BATTELLE MEMORIAL INSTITUTE (US) 2006-01-31 US claimed
US-6923786-B2 Silicone elastomer material for use with enteric feeding device KIMBERLY-CLARK WORLDWIDE, INC. (US) 2005-08-02 US claimed
EP-1337897-A4 PHOTOPATTERNABLE SORBENT AND FUNCTIONALIZED FILMS BATTELLE MEMORIAL INSTITUTE (US) 2004-08-04 EP claimed
WO-2002036652-A9 PHOTOPATTERNABLE SORBENT AND FUNCTIONALIZED FILMS BATTELLE MEMORIAL INSTITUTE (US) 2004-04-29 WO claimed
EP-1337897-A2 PHOTOPATTERNABLE SORBENT AND FUNCTIONALIZED FILMS BATTELLE MEMORIAL INSTITUTE (US) 2003-08-27 EP claimed
US-20020193753-A1 Silicone elastomer material for use with enteric feeding device AVANOS MEDICAL SALES, LLC 2002-12-19 US claimed
EP-1235542-A1 SILICONE ELASTOMER MATERIAL FOR USE WITH ENTERIC FEEDING DEVICE BALLARD MEDICAL PRODUCTS (US) 2002-09-04 EP claimed
US-4427801-A VINYL ENDCAPPED POLYSILOXANE, ORGANOHYDROGEN POLYSILOXANE, SILICA FILLER DOW CORNING CORPORATION (US) 1984-01-24 US claimed
EP-0091737-A2 Extrudable silicone elastomer compositions DOW CORNING CORPORATION (US) 1983-10-19 EP claimed
US-4163081-A POLYSILOXANES ENDCAPPED WITH VINYL-CONTAINING GROUP, AMIDOSILOXANE DOW CORNING CORPORATION (US) 1979-07-31 US claimed
US-4162243-A REINFORCING SILICA, CROSSLINKING DOW CORNING CORPORATION (US) 1979-07-24 US claimed
US-4100627-A CROSSLINKED POLYDIMETHYLSILOXANE DOW CORNING CORPORATION (US) 1978-07-18 US claimed
US-4087585-A TWO-PACKAGE ADHESIVE, EPOXY SILOXANES DOW CORNING CORPORATION (US) 1978-05-02 US claimed
US-4066603-A POLYDIMETHYLSILOXANES, MERCAPTOORGANOPOLYSILOXANES, ORGANIC PEROXIDES DOW CORNING CORPORATION (US) 1978-01-03 US claimed
US-4039504-A Mercaptosiloxane elastomer and method of preparation DOW CORNING CORPORATION (US) 1977-08-02 US claimed
US-4026835-A Method of preparing heat cured siloxane foams using rhodium catalyst and foams prepared therefrom DOW CORNING CORPORATION (US) 1977-05-31 US claimed
US-4026842-A ORGANO-HYDROGEN SILOXANES DOW CORNING CORPORATION (US) 1977-05-31 US claimed