Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.31 |
| ▸ | SELE | P16581 | 1/20 | 0.31 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.31 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | CCNC | P24863 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.31 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | DDO | Q99489 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3843835 | 0.82 | GPR35 (0.31) | GPR35KDM4ELMNAHCAR2MEN1 | |
| SCHEMBL535543 | 0.64 | HAVCR2 (0.47) | HAVCR2ICAM1SELEVCAM1KDM4E | |
| SCHEMBL28064659 | 0.62 | MCL1 (0.50) | HAVCR2GPR35KDM4ELMNAMEN1 | |
| SCHEMBL8692545 | 0.62 | GPR35 (0.42) | GPR35TSHR | |
| SCHEMBL2662567 | 0.62 | EGFR (0.54) | KDM4EMEN1ALDH1A1KMT2ATSHR | |
| SCHEMBL1431321 | 0.60 | HTT (0.53) | KDM4ELMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL3667385 | 0.60 | ALDH1A1 (0.42) | HAVCR2ICAM1SELEVCAM1KDM4E | |
| SCHEMBL111872 | 0.60 | HCAR2 (0.46) | ICAM1SELEVCAM1KDM4ELMNA | |
| SCHEMBL28341246 | 0.59 | KDM4E (0.42) | KDM4ELMNACDK8MEN1ALDH1A1 | |
| Fluoroacetate SCHEMBL28805798 | 0.59 | P2RX7 (0.35) | HAVCR2ICAM1SELEVCAM1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099796-A1 | AZA-INDOLYL COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008067481-A1 | AZA-INDOLYL COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2008-06-05 | — | — | WO | disclosed |