Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | DDO | Q99489 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3853417 | 0.82 | HAVCR2 (0.33) | GPR35HCAR2KDM4EMEN1ALDH1A1 | |
| SCHEMBL24756083 | 0.62 | GPR35 (0.45) | GPR35KDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL2662567 | 0.62 | EGFR (0.54) | KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL1432563 | 0.60 | HTT (0.43) | KDM4EKMT2A | |
| SCHEMBL24808960 | 0.60 | KDM4E (0.42) | HCAR2KDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL695984 | 0.60 | HCAR2 (0.46) | HCAR2KDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL19332460 | 0.60 | ALOX15 (0.40) | GPR35KDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL8138907 | 0.59 | TUBB4A (0.44) | KDM4EMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL70438 | 0.58 | — | — | |
| SCHEMBL11277818 | 0.58 | USP2 (0.44) | GPR35KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099796-A1 | AZA-INDOLYL COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008067481-A1 | AZA-INDOLYL COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2008-06-05 | — | — | WO | disclosed |