SCHEMBL385370

SCHEMBL385370

COC(=O)c1ccc(C(F)(F)F)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.60
CES2 O00748 1/20 0.59
CES1 P23141 1/20 0.59
CA1 P00915 2/20 0.57
CA2 P00918 2/20 0.57
TDP1 Q9NUW8 1/20 0.57
CA12 O43570 1/20 0.57
CA7 P43166 1/20 0.57
CA9 Q16790 1/20 0.57
CA14 Q9ULX7 1/20 0.57
MAPT P10636 1/20 0.57
NOTUM Q6P988 2/20 0.56
CFTR P13569 1/20 0.54
TSHR P16473 1/20 0.54
ALDH1A1 P00352 1/20 0.52
SRD5A2 P31213 1/20 0.52
TRPV1 Q8NER1 2/20 0.51
NPC1 O15118 1/20 0.51
RAB9A P51151 1/20 0.51
ATM Q13315 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ammonia Solution, Strong SCHEMBL27316369 0.98 LMNA (0.59) LMNACES2CES1CA1CA2
SCHEMBL13063663 0.94 LMNA (0.56) LMNACES2CES1CA1CA2
SCHEMBL2271347 0.94 LMNA (0.56) LMNACES2CES1CA1CA2
Methylene Chloride SCHEMBL28147089 0.93 LMNA (0.55) LMNACES2CES1CA1CA2
SCHEMBL31575935 0.93 SRD5A2 (0.65) LMNACES2CES1CA1CA2
Bromoethane SCHEMBL27454009 0.91 NOTUM (0.57) LMNACES2CES1CA1CA2
SCHEMBL1782842 0.91 LMNA (0.69) LMNACES2CES1CA1CA2
SCHEMBL7847608 0.91 PTPN1 (0.60) LMNACES2CES1CA1CA2
SCHEMBL25216636 0.89 LMNA (0.52) LMNACES2CES1CA1CA2
SCHEMBL6709264 0.89 CYP1A1 (0.58) LMNACA1CA2MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 461 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120020114-A Preparation method of N-alkenyl amide compound 中国石油化工股份有限公司 2025-05-20 CN claimed
CN-120020115-A Process for the preparation of N- (alkyl-2-hydroxy) alkylamides and N-alkenylamides 中国石油化工股份有限公司 2025-05-20 CN claimed
CN-110357914-B Application of trisilamine rare earth complex in preparation of boric acid ester by catalyzing reaction of ester and borane 苏州大学 2022-02-25 CN claimed
CN-110357914-A Three silicon amine rare earth compoundings prepare the application in borate in catalysis ester and borine reaction 苏州大学 2019-10-22 CN claimed
US-10224485-B2 Process for preparing a crystalline organic semiconductor material BASF SE (DE) 2019-03-05 US claimed
US-20170012208-A1 ORGANIC SEMICONDUCTOR FORMULATIONS USINVEST LLC 2017-01-12 US claimed
US-20150322094-A1 USE OF SUBSTITUTED 2,3-DIHYDRO-1-BENZOFURAN-4-CARBOXYLIC ACIDS OR SALTS THEREOF AS ACTIVE SUBSTANCES AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2015-11-12 US claimed
EP-2892343-A1 USE OF SUBSTITUTED 2,3-DIHYDRO-1-BENZOFURAN-4-CARBOXYLIC ACIDS OR SALTS THEREOF AS ACTIVE SUBSTANCES AGAINST ABIOTIC PLANT STRESS Bayer CropScience AG (DE) 2015-07-15 EP claimed
US-8952083-B2 Fluorocopolymer composition and its production process ASAHI GLASS COMPANY, LIMITED (JP) 2015-02-10 US claimed
WO-2014037349-A1 USE OF SUBSTITUTED 2,3-DIHYDRO-1-BENZOFURAN-4-CARBOXYLIC ACIDS OR SALTS THEREOF AS ACTIVE SUBSTANCES AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2014-03-13 WO claimed
US-4397763-A TITANIUM-BASED PHILLIPS PETROLEUM COMPANY (US) 1983-08-09 US claimed
US-4330648-A MIXTURE OF TITANIUM HALIDE, MAGNESIUM OR MANGANOUS CHLORIDE DIHYDROCARBYLALUMINUM HALIDE OR HYDRIDE AND AN ETHER-ALCOHOL PHILLIPS PETROLEUM COMPANY (US) 1982-05-18 US claimed
US-4312784-A TITANIUM HALIDE, LEWIS BASE, MAGNESIUM OR MANGANOUS CHLORIDE, UNSATURATED HYDROCARBON AND TRIHYDROCARBYLALUMNIUM PHILLIPS PETROLEUM CO. (US) 1982-01-26 US claimed
US-4242480-A TWO OR THREE COMPONENT SYSTEM COMPRISING A TITANIUM HALIDE, LEWIS BASE, MAGNESIUM OR MANGANESE CHLORIDE, UNSATURATED HYDROCARBON, ORGANOALUMINUM COMPOUND PHILLIPS PETROLEUM COMPANY (US) 1980-12-30 US claimed
EP-0002522-A1 Process for polymerizing butene-1 PHILLIPS PETROLEUM COMPANY (US) 1979-06-27 EP claimed
EP-0002521-A1 Titanium-magnesium/manganese-aluminum catalyst and process for olefin polymerization PHILLIPS PETROLEUM COMPANY (US) 1979-06-27 EP claimed
WO-2026087883-A1 COMPLEXES FOR USE AS CATALYSTS FOR HYDROSILYLATION REACTIONS JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) 2026-04-30 WO disclosed
EP-4731611-A1 TARGETED DEGRADERS OF HIV-1 NEF FOR THE TREATMENT OF HIV DISEASE UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2026-04-29 EP disclosed
US-4242480-A TWO OR THREE COMPONENT SYSTEM COMPRISING A TITANIUM HALIDE, LEWIS BASE, MAGNESIUM OR MANGANESE CHLORIDE, UNSATURATED HYDROCARBON, ORGANOALUMINUM COMPOUND PHILLIPS PETROLEUM COMPANY (US) 1980-12-30 US disclosed
US-3932450-A Intermediates in the preparation of imidazo(2,1-alpha)isoindoles SANDOZ, INC. (US) 1976-01-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150322094-A1 USE OF SUBSTITUTED 2,3-DIHYDRO-1-BENZOFURAN-4-CARBOXYLIC ACIDS OR SALTS THEREOF AS ACTIVE SUBSTANCES AGAINST ABIOTIC PLANT STRESS CAT, HSF1, HPD LMNA 4642/4885CES2 1061/4885CES1 1114/4885
US-10224485-B2 Process for preparing a crystalline organic semiconductor material STOM, SPOP, TTR LMNA 2511/4885CES2 3220/4885CES1 3095/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.