Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.56 |
| ▸ | TSHR | P16473 | 4/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylamine SCHEMBL28839542 | 0.94 | HSD17B10 (0.53) | ALDH1A1HSD17B10TSHRALOX12ALOX15 | |
| SCHEMBL13769436 | 0.85 | PTGS1 (0.46) | ALDH1A1HSD17B10TSHRALOX12ALOX15 | |
| SCHEMBL14041544 | 0.85 | ALDH1A1 (0.59) | ALDH1A1HSD17B10TSHRALOX12ALOX15 | |
| SCHEMBL9652406 | 0.84 | ALDH1A1 (0.52) | ALDH1A1HSD17B10TSHRALOX12ALOX15 | |
| SCHEMBL18133126 | 0.83 | HPGD (0.50) | TSHRLMNAL3MBTL1PTGS1PTGS2 | |
| SCHEMBL20782071 | 0.82 | ALDH1A1 (0.54) | ALDH1A1HSD17B10TSHRALOX12ALOX15 | |
| SCHEMBL3437767 | 0.82 | NPC1 (0.45) | TSHRLMNAPTGS1PTGS2CYP2C9 | |
| SCHEMBL22636511 | 0.80 | ESR1 (0.50) | ALDH1A1HSD17B10TSHRALOX12ALOX15 | |
| SCHEMBL998287 | 0.80 | ESR1 (0.50) | ALDH1A1HSD17B10TSHRALOX12ALOX15 | |
| SCHEMBL20715474 | 0.80 | SMN1; SMN2 (0.59) | TSHRHIF1ALMNAHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11731943-B2 | Therapeutic compounds, compositions and methods of use thereof | GENENTECH, INC. (US) | 2023-08-22 | — | — | US | disclosed |
| US-11731943-B2 | Therapeutic compounds, compositions and methods of use thereof | GENENTECH, INC. (US) | 2023-08-22 | — | — | US | disclosed |
| US-20220352466-A1 | ORGANIC ELECTROLUMINESCENCE DEVICE | SAMSUNG DISPLAY CO., LTD. (KR) | 2022-11-03 | — | — | US | disclosed |
| US-20210179564-A1 | THERAPEUTIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2021-06-17 | — | — | US | disclosed |
| US-20190071404-A1 | THERAPEUTIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2019-03-07 | — | — | US | disclosed |
| CN-1768029-B | Aromatic amine derivative and organic electroluminescent element using the same | IDEMITSU KOSAN CO.,LTD. (JP) | 2012-02-08 | — | — | CN | disclosed |
| CN-101789496-B | Aromatic amine derivative and organic electroluminescent element using the same | IDEMITSU KOSAN CO.,LTD. (JP) | 2011-12-28 | — | — | CN | disclosed |
| CN-101789496-A | Aromatic amine derivative and organic electroluminescent element using the same | IDEMITSU KOSAN CO | 2010-07-28 | — | — | CN | disclosed |
| US-7586006-B2 | Aromatic amine derivative and organic electroluminescent element employing the same | IDEMITSU KOSAN CO., LTD. (JP) | 2009-09-08 | — | — | US | disclosed |
| US-7579479-B2 | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-08-25 | — | — | US | disclosed |
| US-7241780-B2 | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method | BRISTOLS-MYERS SQUIBB COMPANY (US) | 2007-07-10 | — | — | US | disclosed |
| US-20070015797-A1 | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method | CHENG PETER T | 2007-01-18 | — | — | US | disclosed |
| US-20060202190-A1 | Aromatic amine derivative and organic electroluminescent element employing the same | IDEMITSU KOSAN CO., LTD. (JP) | 2006-09-14 | — | — | US | disclosed |
| CN-1768029-A | Aromatic amine derivative and organic electroluminescent element using the same | IDEMITSU KOSAN CO (JP) | 2006-05-03 | — | — | CN | disclosed |
| EP-1612202-A1 | AROMATIC AMINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT ELEMENT EMPLOYING THE SAME | IDEMITSU KOSAN CO., LTD. (JP) | 2006-01-04 | — | — | EP | disclosed |
| EP-0650955-B1 | Amine compound and electro-luminescence device comprising same | HODOGAYA CHEMICAL CO LTD (JP) | 1998-08-19 | — | — | EP | disclosed |
| US-5707747-A | CHARGE TRANSPORT COMPOUNDS | HODOGAYA CHEMICAL CO., LTD. (JP) | 1998-01-13 | — | — | US | disclosed |
| US-5639914-A | DURABLE, STABLE, LOW VOLTAGE ELECTROLUMINESCENT EMITTERS | HODOGAYA CHEMICAL CO., LTD. (JP) | 1997-06-17 | — | — | US | disclosed |
| EP-0650955-A1 | Amine compound and electro-luminescence device comprising same | HODOGAYA CHEMICAL CO., LTD. (JP) | 1995-05-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190071404-A1 | THERAPEUTIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | JAK2, JAK1, JAK3 | ALDH1A1 1808/4885HSD17B10 2047/4885TSHR 4145/4885 |
| US-11731943-B2 | Therapeutic compounds, compositions and methods of use thereof | JAK2, JAK1, JAK3 | ALDH1A1 1808/4885HSD17B10 2047/4885TSHR 4145/4885 |
| US-20210179564-A1 | THERAPEUTIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | JAK2, JAK1, JAK3 | ALDH1A1 1808/4885HSD17B10 2047/4885TSHR 4145/4885 |
| US-20060202190-A1 | Aromatic amine derivative and organic electroluminescent element employing the same | TYR, MAOA, MAOB | ALDH1A1 89/4885HSD17B10 3861/4885TSHR 3155/4885 |
| US-20070015797-A1 | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method | GPR119, LIPC, ACACA | ALDH1A1 1055/4885HSD17B10 209/4885TSHR 780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.