SCHEMBL385455

SCHEMBL385455

N#Cc1cc(F)ccc1B(O)O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPV4 Q9HBA0 1/20 0.34
MAOA P21397 1/20 0.34
MAOB P27338 1/20 0.34
ENPP2 Q13822 2/20 0.33
CYP11B1 P15538 1/20 0.33
CYP11B2 P19099 1/20 0.33
SLC22A12 Q96S37 1/20 0.33
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
RXFP1 Q9HBX9 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
FFAR1 O14842 1/20 0.33
FFAR4 Q5NUL3 1/20 0.33
AR P10275 2/20 0.33
CES2 O00748 1/20 0.32
CES1 P23141 1/20 0.32
ORAI1 Q96D31 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29951411 1.00 TRPV4 (0.34) TRPV4MAOAMAOBENPP2CYP11B1
SCHEMBL2732608 0.90 GRM4 (0.33) ENPP2AR
SCHEMBL16052048 0.84 FFAR4 (0.38) TRPV4MAOAMAOBENPP2CYP11B1
SCHEMBL29956185 0.84 FFAR4 (0.38) TRPV4MAOAMAOBENPP2CYP11B1
SCHEMBL18105634 0.80 SLC22A12 (0.38) TRPV4MAOAMAOBCYP11B1CYP11B2
SCHEMBL177542 0.79 AR (0.44) SLC22A12KDM4EALDH1A1NPSR1RXFP1
SCHEMBL23191268 0.78 ENPP2 (0.48) ENPP2ALDH1A1FFAR1AR
SCHEMBL30537828 0.78 ENPP2 (0.48) ENPP2ALDH1A1FFAR1AR
SCHEMBL15031886 0.78 ALDH1A1 (0.38) MAOAMAOBENPP2KDM4EALDH1A1
SCHEMBL29956199 0.78 AR (0.44) ENPP2AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4594318-A1 AKT1 MODULATORS Alterome Therapeutics, Inc. (US) 2025-08-06 EP disclosed
US-20250092040-A1 AKT1 MODULATORS ALTEROME THERAPEUTICS, INC. 2025-03-20 US disclosed
US-12116369-B2 Substituted pyrazolo[1,5-a]pyrimidines as glucocerebrosidase activators Bial—R&D Investments, S.A. (PT) 2024-10-15 US disclosed
US-20240239797-A1 AKT1 MODULATORS ALTEROME THERAPEUTICS, INC. 2024-07-18 US disclosed
US-20240239807-A1 SARS-COV2 MAIN PROTEASE INHIBITORS GILEAD SCIENCES, INC. 2024-07-18 US disclosed
US-11999730-B1 AKT1 modulators ALTEROME THERAPEUTICS, INC. (US) 2024-06-04 US disclosed
US-20240174667-A1 AKT1 MODULATORS ALTEROME THERAPEUTICS, INC. 2024-05-30 US disclosed
CN-117946080-A Organic molecules, in particular for organic optoelectronic devices 三星显示有限公司 2024-04-30 CN disclosed
US-20240116946-A1 SARS-COV2 MAIN PROTEASE INHIBITORS GILEAD SCIENCES, INC. 2024-04-11 US disclosed
WO-2024073371-A1 AKT1 MODULATORS ALTEROME THERAPEUTICS, INC. (US) 2024-04-04 WO disclosed
US-20120322823-A1 HETEROCYCLIC SULFONAMIDES, USES AND PHARMACEUTICAL COMPOSITIONS THEREOF PFIZER INC. 2012-12-20 US disclosed
US-8278457-B2 Heterocyclic sulfonamides, uses and pharmaceutical compositions thereof PFIZER INC. (US) 2012-10-02 US disclosed
EP-2445883-A1 HETEROCYCLIC SULFONAMIDES, USES AND PHARMACEUTICAL COMPOSITIONS THEREOF Pfizer Inc. (US) 2012-05-02 EP disclosed
US-8101632-B2 5-furopyridinone substituted indazoles ALBANY MOLECULAR RESEARCH, INC. (US) 2012-01-24 US disclosed
WO-2011116951-A1 PHARMACEUTICALLY ACTIVE DISUBSTITUTED TRIAZINE DERIVATIVES LEAD DISCOVERY CENTER GMBH (DE) 2011-09-29 WO disclosed
US-20110105533-A1 Heterocyclic Sulfonamides, Uses and Pharmaceutical Compositions Thereof PFIZER INC. 2011-05-05 US disclosed
WO-2010150192-A1 HETEROCYCLIC SULFONAMIDES, USES AND PHARMACEUTICAL COMPOSITIONS THEREOF PFIZER INC. (US) 2010-12-29 WO disclosed
US-20090318439-A1 5-FUROPYRIDINONE SUBSTITUTED INDAZOLES ALBANY MOLECULAR RESEARCH, INC. (US) 2009-12-24 US disclosed
EP-2125826-A1 5-FUROPYRIDINONE SUBSTITUTED INDAZOLES Albany Molecular Research, Inc. (US) 2009-12-02 EP disclosed
WO-2008086409-A1 5-FUROPYRIDINONE SUBSTITUTED INDAZOLES ALBANY MOLECULAR RESEARCH, INC. (US) 2008-07-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240239797-A1 AKT1 MODULATORS AKT1S1, AKT1, AKT2 TRPV4 4802/4885MAOA 4781/4885MAOB 4603/4885
US-12116369-B2 Substituted pyrazolo[1,5-a]pyrimidines as glucocerebrosidase activators GBA1, GALC, GBA3 TRPV4 3380/4885MAOA 284/4885MAOB 343/4885
US-20240116946-A1 SARS-COV2 MAIN PROTEASE INHIBITORS ACE2, TMPRSS2, ACE TRPV4 3399/4885MAOA 2527/4885MAOB 1582/4885
US-20110105533-A1 Heterocyclic Sulfonamides, Uses and Pharmaceutical Compositions Thereof STS, SULT2A1, SULT1A1 TRPV4 2277/4885MAOA 1110/4885MAOB 758/4885
US-20120322823-A1 HETEROCYCLIC SULFONAMIDES, USES AND PHARMACEUTICAL COMPOSITIONS THEREOF STS, SULT2A1, SULT1A1 TRPV4 2277/4885MAOA 1110/4885MAOB 758/4885
US-20240239807-A1 SARS-COV2 MAIN PROTEASE INHIBITORS ACE2, TMPRSS2, ACE TRPV4 3399/4885MAOA 2527/4885MAOB 1582/4885
US-20090318439-A1 5-FUROPYRIDINONE SUBSTITUTED INDAZOLES MCHR1, PRMT5, PRMT1 TRPV4 742/4885MAOA 1818/4885MAOB 1545/4885
US-20250092040-A1 AKT1 MODULATORS AKT1S1, AKT1, AKT2 TRPV4 4802/4885MAOA 4781/4885MAOB 4603/4885
US-11999730-B1 AKT1 modulators AKT1S1, AKT1, AKT2 TRPV4 4802/4885MAOA 4781/4885MAOB 4603/4885
US-20240174667-A1 AKT1 MODULATORS AKT1S1, AKT1, AKT2 TRPV4 4802/4885MAOA 4781/4885MAOB 4603/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.