Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | PLA2G2A | P14555 | 11/20 | 0.57 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | PPARG | P37231 | 5/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3855197 | 0.88 | GRIK2 (0.64) | TSHRMAPK1KMT2APLA2G2APLA2G1B | |
| SCHEMBL3857137 | 0.86 | PLA2G2A (0.61) | TSHRMAPK1KMT2APLA2G2APLA2G1B | |
| SCHEMBL3854712 | 0.84 | PLA2G2A (0.55) | KMT2APLA2G2AMAPTPPARGALDH1A1 | |
| SCHEMBL3853126 | 0.83 | MAPT (0.48) | TSHRMAPK1KMT2APLA2G2APLA2G1B | |
| SCHEMBL3853074 | 0.83 | PLA2G2A (0.61) | KMT2APLA2G2APLA2G1BMAPTPPARG | |
| SCHEMBL3852753 | 0.83 | PLA2G2A (0.53) | PLA2G2APLA2G1BMAPTPPARGTP53 | |
| SCHEMBL3853483 | 0.78 | PLA2G2A (0.49) | KMT2APLA2G2APLA2G1BMAPTTP53 | |
| SCHEMBL3854484 | 0.78 | PLK4 (0.43) | KMT2APLA2G2AMAPTPPARGNPSR1 | |
| SCHEMBL3853542 | 0.78 | GRIK2 (0.56) | KMT2APLA2G2AMAPTTP53ALDH1A1 | |
| SCHEMBL10627225 | 0.77 | MAPT (0.67) | TSHRMAPK1KMT2APLA2G2APLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582773-B2 | Substituted phenyl indoles | WYETH (US) | 2009-09-01 | — | — | US | disclosed |
| US-20050070592-A1 | Substituted phenyl indoles | WYETH (US) | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070592-A1 | Substituted phenyl indoles | TPH2, IDO2, AANAT | TSHR 1667/4885MAPK1 3768/4885KMT2A 582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.