Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 9/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TTK | P33981 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44576 | 0.80 | WDR5 (0.46) | WDR5KDM4EALDH1A1BTKSMN1; SMN2 | |
| SCHEMBL38703 | 0.79 | WDR5 (0.44) | WDR5KDM4EALDH1A1HPGDBTK | |
| SCHEMBL44679 | 0.78 | ROCK2 (0.51) | ALDH1A1NPC1RAB9AEPHB4ROCK2 | |
| SCHEMBL39537 | 0.77 | WDR5 (0.46) | WDR5KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL44334 | 0.77 | NPC1 (0.49) | NPC1RAB9AEPHB4HTTROCK2 | |
| SCHEMBL44374 | 0.77 | NAMPT (0.45) | WDR5MAPK1RAB9AHTTROCK2 | |
| SCHEMBL44622 | 0.77 | LMNA (0.50) | WDR5MAPK1KDM4EALDH1A1HPGD | |
| SCHEMBL38716 | 0.76 | FBP1 (0.47) | WDR5KDM4EALDH1A1BTKCYP2C9 | |
| SCHEMBL44512 | 0.75 | WDR5 (0.52) | WDR5KDM4ENPC1 | |
| SCHEMBL13844942 | 0.75 | WDR5 (0.52) | WDR5KDM4ERAB9AROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |