Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | WDR5 | P61964 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 3/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44576 | 0.79 | WDR5 (0.46) | WDR5MAPTBTKKDM4EALDH1A1 | |
| SCHEMBL38703 | 0.78 | WDR5 (0.44) | CYP2C9WDR5NAMPTBTKKDM4E | |
| SCHEMBL44622 | 0.78 | LMNA (0.50) | WDR5MAPTKDM4EALDH1A1 | |
| SCHEMBL44668 | 0.77 | CYP19A1 (0.56) | MAPTNAMPTPIK3CDPIK3CGKDM4E | |
| SCHEMBL44344 | 0.77 | TP53 (0.45) | NAMPTPIK3CDPIK3CGALDH1A1SMN1; SMN2 | |
| SCHEMBL38565 | 0.76 | WDR5 (0.44) | CYP2C9WDR5BTKKDM4EALDH1A1 | |
| SCHEMBL39537 | 0.76 | WDR5 (0.46) | WDR5MAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL13844942 | 0.75 | WDR5 (0.52) | CYP2C9WDR5KDM4ESMN1; SMN2 | |
| SCHEMBL44512 | 0.75 | WDR5 (0.52) | WDR5MAPTNAMPTKDM4E | |
| SCHEMBL44679 | 0.75 | ROCK2 (0.51) | MAPTNAMPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |