Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.51 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.51 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.46 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 4/20 | 0.45 |
| ▸ | THRB | P10828 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3848774 | 0.92 | HDAC1 (0.50) | HDAC1HDAC6PLA2G2APTGDR2GFER | |
| SCHEMBL3855367 | 0.91 | HDAC1 (0.49) | HDAC1HDAC6PLA2G2AP2RX4PTGDR2 | |
| SCHEMBL3848975 | 0.91 | LMNA (0.55) | HDAC1HDAC6PLA2G2APTGDR2GFER | |
| SCHEMBL3853781 | 0.88 | HDAC1 (0.49) | HDAC1HDAC6PLA2G2APTGDR2GFER | |
| SCHEMBL3848949 | 0.88 | HDAC1 (0.47) | HDAC1HDAC6PLA2G2APTGDR2GFER | |
| SCHEMBL3855485 | 0.87 | PLA2G2A (0.50) | HDAC1HDAC6PLA2G2APTGDR2GFER | |
| SCHEMBL3848329 | 0.85 | KDM4E (0.50) | HDAC1HDAC6PLA2G2APTGDR2GFER | |
| SCHEMBL3854421 | 0.80 | HDAC1 (0.48) | HDAC1HDAC6PLA2G2APTGDR2GFER | |
| SCHEMBL3854166 | 0.80 | PLA2G2A (0.47) | HDAC1HDAC6PLA2G2AGFERKDM4E | |
| SCHEMBL3858093 | 0.79 | PLA2G2A (0.48) | HDAC1HDAC6PLA2G2APTGDR2GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7576222-B2 | N-{[4-(but-2-ynyloxy)phenyl]sulfonyl}-1-(2-fluorobenzyl)-5-methoxy-2-methyltryptophan; for treatment of rheumatoid arthritis, juvenile rheumatoid arthritis, ulcerative colitis, or Crohn's disease | WYETH (US) | 2009-08-18 | — | — | US | disclosed |
| US-20060160884-A1 | Alkynyl-containing tryptophan derivative inhibitors of tace/matrix metalloproteinase | WYETH (US) | 2006-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160884-A1 | Alkynyl-containing tryptophan derivative inhibitors of tace/matrix metalloproteinase | ADAM17, TPSAB1, ADAM10 | HDAC1 589/4885HDAC6 571/4885PLA2G2A 3197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.