Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 4/20 | 0.38 |
| ▸ | BRAF | P15056 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | P62805 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4473204 | 0.87 | NPC1 (0.41) | RAF1BRAFMAPTKMT2ACYP2C19 | |
| SCHEMBL3856725 | 0.84 | RAF1 (0.37) | RAF1BRAFMAPTKMT2ACYP2C19 | |
| SCHEMBL5038620 | 0.84 | POLB (0.51) | MAPTKMT2AALDH1A1POLBGAA | |
| SCHEMBL2301431 | 0.81 | RAF1 (0.54) | RAF1BRAFMAPTKMT2ACYP2C19 | |
| SCHEMBL4469804 | 0.79 | HTT (0.46) | RAF1BRAFMAPTKMT2ACYP2C19 | |
| SCHEMBL3855951 | 0.79 | NPSR1 (0.48) | RAF1BRAFMAPTKMT2ACYP2C19 | |
| SCHEMBL3850936 | 0.79 | GPR35 (0.43) | RAF1BRAFMAPTKMT2ACYP2C19 | |
| SCHEMBL4470605 | 0.79 | NPC1 (0.40) | RAF1BRAFMAPTKMT2ACYP2C19 | |
| SCHEMBL1469056 | 0.78 | RAF1 (0.45) | RAF1BRAFMAPTKMT2ACYP2C19 | |
| SCHEMBL4459109 | 0.77 | RAF1 (0.41) | RAF1BRAFMAPTKMT2ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-A1 | METHODS OF USING MEK INHIBITORS | Exelixis, Inc. (US) | 2009-09-23 | — | — | EP | claimed |
| WO-2008076415-A1 | METHODS OF USING MEK INHIBITORS | EXELIXIS, INC. (US) | 2008-06-26 | — | — | WO | claimed |