Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4459109 | 0.88 | RAF1 (0.41) | HTTHPGDKMT2AMEN1MAPT | |
| SCHEMBL3848659 | 0.88 | MEN1 (0.52) | HTTNPC1RAB9AHPGDKMT2A | |
| SCHEMBL4462942 | 0.88 | FADS1 (0.49) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL27901583 | 0.87 | RXFP1 (0.55) | — | |
| SCHEMBL27919273 | 0.85 | FADS1 (0.51) | HTTHPGDKMT2AMEN1MAPT | |
| SCHEMBL4464511 | 0.85 | MAPT (0.44) | HTTNPC1RAB9AHPGDKMT2A | |
| SCHEMBL3848177 | 0.85 | MAPT (0.44) | HTTNPC1RAB9AHPGDKMT2A | |
| SCHEMBL4473204 | 0.81 | NPC1 (0.41) | NPC1RAB9AHPGDKMT2AMAPT | |
| SCHEMBL3857514 | 0.79 | RAF1 (0.38) | HTTNPC1RAB9AHPGDKMT2A | |
| SCHEMBL3850936 | 0.79 | GPR35 (0.43) | NPC1RAB9AHPGDKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |