Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA3 | P07451 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6468746 | 0.80 | KDM4E (0.51) | ALDH1A1HSD17B10KDM4EKMT2AMEN1 | |
| SCHEMBL2128507 | 0.80 | KEAP1 (0.68) | KEAP1RECQLALDH1A1HSD17B10KDM4E | |
| SCHEMBL11136620 | 0.77 | PSIP1 (0.39) | ALDH1A1HSD17B10KDM4EHPGDKMT2A | |
| SCHEMBL21624555 | 0.77 | PSIP1 (0.64) | ALDH1A1MAPTGAALMNAHTT | |
| SCHEMBL6420978 | 0.77 | PSIP1 (0.39) | ALDH1A1HSD17B10KDM4EHPGDKMT2A | |
| SCHEMBL16301364 | 0.77 | ALDH1A1 (0.45) | KEAP1ALDH1A1MAPTL3MBTL1HTT | |
| SCHEMBL6006407 | 0.76 | KEAP1 (0.54) | KEAP1RECQLALDH1A1HSD17B10KDM4E | |
| SCHEMBL7441407 | 0.75 | KEAP1 (0.67) | KEAP1RECQLALDH1A1HSD17B10KDM4E | |
| SCHEMBL28028822 | 0.75 | GLO1 (0.62) | KEAP1RECQLALDH1A1HSD17B10KDM4E | |
| SCHEMBL10808948 | 0.75 | KEAP1 (0.57) | KEAP1RECQLALDH1A1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833816-B1 | SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | claimed |