Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 1/20 | 0.35 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | ANPEP | P15144 | 1/20 | 0.31 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.31 |
| ▸ | GBA1 | P04062 | 1/20 | 0.30 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3867999 | 0.84 | CFD (0.44) | CFDTPSB2ASIC3ANPEPENPEP | |
| SCHEMBL3859065 | 0.79 | CFD (0.48) | CFDTPSB2ASIC3ANPEPENPEP | |
| SCHEMBL237225 | 0.78 | OPRK1 (0.35) | PTGDR2ASIC3GRM4 | |
| SCHEMBL16151063 | 0.77 | CYP2A6 (0.44) | — | |
| SCHEMBL21507539 | 0.76 | GRM4 (0.47) | CFDTPSB2S1PR1GRM4 | |
| SCHEMBL12488284 | 0.76 | GRM4 (0.47) | CFDTPSB2S1PR1GRM4 | |
| SCHEMBL25269085 | 0.75 | PNMT (0.47) | CFDTPSB2GBA1 | |
| SCHEMBL382070 | 0.75 | PNMT (0.47) | CFDTPSB2GBA1 | |
| SCHEMBL3870082 | 0.75 | HTR2A (0.46) | CFDTPSB2ASIC3 | |
| SCHEMBL3862593 | 0.75 | PTGES (0.38) | CFDTPSB2ANPEPENPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076122-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | disclosed |