Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
| ▸ | TUBB | P07437 | 1/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.42 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.42 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.42 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.42 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.42 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28411694 | 0.86 | CYP2C9 (0.42) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL3859514 | 0.86 | KCNH2 (0.49) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL28419354 | 0.81 | CYP2C9 (0.61) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL3859368 | 0.78 | KMT2A (0.45) | CYP2C9CYP2C19CYP3A4CYP1A2KCNH2 | |
| SCHEMBL3859680 | 0.76 | CRHR1 (0.34) | CRHR1SMN1; SMN2 | |
| SCHEMBL26463971 | 0.76 | TUBB4A (0.54) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL14203642 | 0.75 | TUBB4A (0.57) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL3867946 | 0.72 | ADORA2A (0.40) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL1715486 | 0.72 | CRHR1 (0.34) | CRHR1 | |
| SCHEMBL3869447 | 0.72 | CYP2C9 (0.59) | ADORA1CYP2C9CYP2C19CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324223-B2 | Substituted thieno [2,3-d] pyrimidines as HIV inhibitors | ARDEA BIOSCIENCES, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-8324223-B2 | Substituted thieno [2,3-d] pyrimidines as HIV inhibitors | ARDEA BIOSCIENCES, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-8324223-B2 | Substituted thieno [2,3-d] pyrimidines as HIV inhibitors | ARDEA BIOSCIENCES, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-20120225894-A1 | Substituted Thienol[2,3-d] pyrimidines as HIV Inhibitors | ARDEA BIOSCIENCES, INC. (US) | 2012-09-06 | — | — | US | disclosed |
| US-20120225894-A1 | Substituted Thienol[2,3-d] pyrimidines as HIV Inhibitors | ARDEA BIOSCIENCES, INC. (US) | 2012-09-06 | — | — | US | disclosed |
| US-20120225894-A1 | Substituted Thienol[2,3-d] pyrimidines as HIV Inhibitors | ARDEA BIOSCIENCES, INC. (US) | 2012-09-06 | — | — | US | disclosed |
| US-8211898-B2 | Substituted thieno[3,2-d]pyrimidines as HIV inhibitors | ARDEA BIOSCIENCES, INC. (US) | 2012-07-03 | — | — | US | disclosed |
| US-8211898-B2 | Substituted thieno[3,2-d]pyrimidines as HIV inhibitors | ARDEA BIOSCIENCES, INC. (US) | 2012-07-03 | — | — | US | disclosed |
| US-8211898-B2 | Substituted thieno[3,2-d]pyrimidines as HIV inhibitors | ARDEA BIOSCIENCES, INC. (US) | 2012-07-03 | — | — | US | disclosed |
| EP-2132211-A2 | 4-CYANOPHENYLAMINO-SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS HIV INHIBITORS | Ardea Biosciences, Inc. (US) | 2009-12-16 | — | — | EP | disclosed |
| US-20090281124-A1 | 4-CYANOPHENYLAMINO-SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS HIV INHIBITORS | ARDEA BIOSCIENCES (US) | 2009-11-12 | — | — | US | disclosed |
| US-20090281124-A1 | 4-CYANOPHENYLAMINO-SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS HIV INHIBITORS | ARDEA BIOSCIENCES (US) | 2009-11-12 | — | — | US | disclosed |
| US-7595324-B2 | Substituted thieno[3,2-D]pyrimidines as HIV inhibitors | ARDEA BIOSCIENCES, INC. (US) | 2009-09-29 | — | — | US | disclosed |
| US-7595324-B2 | Substituted thieno[3,2-D]pyrimidines as HIV inhibitors | ARDEA BIOSCIENCES, INC. (US) | 2009-09-29 | — | — | US | disclosed |
| US-7595324-B2 | Substituted thieno[3,2-D]pyrimidines as HIV inhibitors | ARDEA BIOSCIENCES, INC. (US) | 2009-09-29 | — | — | US | disclosed |
| US-20080176871-A1 | 4-CYANOPHENYLAMINO-SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS HIV INHIBITORS | ARDEA BIOSCIENCES, INC. (US) | 2008-07-24 | — | — | US | disclosed |
| US-20080176871-A1 | 4-CYANOPHENYLAMINO-SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS HIV INHIBITORS | ARDEA BIOSCIENCES, INC. (US) | 2008-07-24 | — | — | US | disclosed |
| US-20080176871-A1 | 4-CYANOPHENYLAMINO-SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS HIV INHIBITORS | ARDEA BIOSCIENCES, INC. (US) | 2008-07-24 | — | — | US | disclosed |
| WO-2008058285-A2 | 4-CYANOPHENYLAMINO-SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS HIV INHIBITORS | ARDEA BIOSCIENCES, INC. (US) | 2008-05-15 | — | — | WO | disclosed |
| WO-2008058285-A2 | 4-CYANOPHENYLAMINO-SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS HIV INHIBITORS | ARDEA BIOSCIENCES, INC. (US) | 2008-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176871-A1 | 4-CYANOPHENYLAMINO-SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS HIV INHIBITORS | CYCS, DCK, NSUN2 | TUBB4A 1861/4885TUBB 1650/4885TUBA3C 1977/4885 |
| US-20120225894-A1 | Substituted Thienol[2,3-d] pyrimidines as HIV Inhibitors | TYMS, DUT, TYMP | TUBB4A 2715/4885TUBB 1809/4885TUBA3C 1588/4885 |
| US-20090281124-A1 | 4-CYANOPHENYLAMINO-SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS HIV INHIBITORS | CYCS, DCK, NSUN2 | TUBB4A 1861/4885TUBB 1650/4885TUBA3C 1977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.