SCHEMBL3864600

SCHEMBL3864600

C[C](C)CNC(=O)c1cccnc1

nearest known ligand 0.75

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.75
KMT2A Q03164 5/20 0.64
MEN1 O00255 4/20 0.64
NPC1 O15118 2/20 0.64
CYP1A2 P05177 1/20 0.64
CYP3A4 P08684 1/20 0.64
HDAC1 Q13547 1/20 0.61
HDAC6 Q9UBN7 1/20 0.61
RAB9A P51151 2/20 0.59
SMN1; SMN2 Q16637 1/20 0.59
TSHR P16473 1/20 0.57
EPHX2 P34913 2/20 0.56
CYP2C9 P11712 1/20 0.56
CYP2C19 P33261 1/20 0.56
GAA P10253 1/20 0.56
LMNA P02545 1/20 0.56
HIF1A Q16665 1/20 0.56
MAPT P10636 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8403704 0.92 THRB (0.73) THRBKMT2AMEN1NPC1CYP1A2
Nicotinuric Acid SCHEMBL30183567 0.86 THRB (0.75) THRBKMT2AMEN1NPC1CYP1A2
Nicotinuric Acid SCHEMBL351962 0.86 THRB (0.75) THRBKMT2AMEN1NPC1CYP1A2
N-Hydroxymethylnicotinamide SCHEMBL352358 0.86 THRB (1.00) THRBKMT2AMEN1NPC1CYP1A2
SCHEMBL290125 0.85 THRB (0.69) THRBKMT2AMEN1NPC1CYP1A2
SCHEMBL289795 0.85 THRB (0.69) THRBKMT2AMEN1NPC1CYP1A2
SCHEMBL13545150 0.85 THRB (0.69) THRBKMT2AMEN1NPC1CYP1A2
Nicotinuric Acid SCHEMBL9227412 0.85 THRB (0.73) THRBKMT2AMEN1NPC1CYP1A2
SCHEMBL1687071 0.85 THRB (0.73) THRBKMT2AMEN1NPC1CYP1A2
Nicotinuric Acid SCHEMBL28292410 0.85 THRB (0.73) THRBKMT2AMEN1NPC1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090048219-A1 ORGANIC NITRIC OXIDE DONOR SALTS OF NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE NITROMED INC. (US) 2009-02-19 US disclosed
EP-1883614-A2 ORGANIC NITRIC OXIDE ENHANCING SALTS OF NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE Nitromed, Inc. (US) 2008-02-06 EP disclosed
EP-1877374-A1 ORGANIC NITRIC OXIDE ENHANCING SALTS OF ANGIOTENSIN CONVERTING ENZYME INHIBITORS, COMPOSITIONS AND METHODS OF USE Nitromed, Inc. (US) 2008-01-16 EP disclosed
EP-1861093-A2 ORGANIC NITRIC OXIDE ENHANCING SALTS OF ANGIOTENSIN II ANTAGONISTS, COMPOSITIONS AND METHODS OF USE Nitromed, Inc. (US) 2007-12-05 EP disclosed
EP-1858525-A2 ORGANIC NITRIC OXIDE DONOR SALTS OF ANTIMICROBIAL COMPOUNDS, COMPOSITIONS AND METHODS OF USE Nitromed, Inc. (US) 2007-11-28 EP disclosed
WO-2007123818-A2 ORGANIC NITRIC OXIDE ENHANCING SALTS OF PROSTAGLANDINS, COMPOSITIONS AND METHODS OF USE NITROMED, INC. (US) 2007-11-01 WO disclosed
WO-2007086884-A2 ORGANIC NITRIC OXIDE DONOR SALTS OF ANTIMICROBIAL COMPOUNDS, COMPOSITIONS AND METHODS OF USE NITROMED, INC. (US) 2007-08-02 WO disclosed
WO-2007016136-A2 ORGANIC NITRIC OXIDE ENHANCING SALTS OF CYCLOOXYGENASE-2 SELECTIVE INHIBITORS, COMPOSITONS AND METHODS OF USE NITROMED, INC. (US) 2007-02-08 WO disclosed
WO-2006127591-A2 ORGANIC NITRIC OXIDE ENHANCING SALTS OF NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE NITROMED, INC. (US) 2006-11-30 WO disclosed
WO-2006102071-A1 ORGANIC NITRIC OXIDE ENHANCING SALTS OF ANGIOTENSIN CONVERTING ENZYME INHIBITORS, COMPOSITIONS AND METHODS OF USE NITROMED, INC. (US) 2006-09-28 WO disclosed
WO-2006099058-A2 ORGANIC NITRIC OXIDE ENHANCING SALTS OF ANGIOTENSIN II ANTAGONISTS, COMPOSITIONS AND METHODS OF USE NITROMED, INC. (US) 2006-09-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090048219-A1 ORGANIC NITRIC OXIDE DONOR SALTS OF NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE NOS3, NOS1, NOS2 THRB 2755/4885KMT2A 4643/4885MEN1 4231/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.