SCHEMBL3866745

SCHEMBL3866745

CCC(=O)COC(=O)CC

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.47
NAAA Q02083 1/20 0.44
ALDH1A1 P00352 6/20 0.40
CYP1A2 P05177 1/20 0.40
HPGD P15428 1/20 0.40
CYP2C19 P33261 1/20 0.40
BLM P54132 1/20 0.40
WRN Q14191 1/20 0.40
HIF1A Q16665 1/20 0.40
GAA P10253 3/20 0.38
MGAM O43451 1/20 0.38
SI P14410 1/20 0.38
MGAM2 Q2M2H8 1/20 0.38
SOAT1 P35610 1/20 0.38
PAM P19021 2/20 0.35
TRPA1 O75762 1/20 0.35
FFAR3 O14843 1/20 0.33
RECQL P46063 1/20 0.33
LMNA P02545 1/20 0.33
HSD17B10 Q99714 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7813401 0.92 NAAA (0.46) TDP1NAAAALDH1A1CYP1A2HPGD
SCHEMBL12189506 0.84 NAAA (0.41) TDP1NAAAALDH1A1CYP1A2HPGD
SCHEMBL14535001 0.82 TDP1 (0.41) TDP1NAAAALDH1A1CYP1A2HPGD
SCHEMBL28131182 0.82 NAAA (0.40) TDP1NAAAALDH1A1CYP1A2HPGD
SCHEMBL11312957 0.82 PAM (0.55) TDP1ALDH1A1CYP1A2PAMLMNA
SCHEMBL28788408 0.82 TDP1 (0.41) TDP1NAAAALDH1A1GAAMGAM
SCHEMBL11587311 0.82 ALDH1A1 (0.50) TDP1NAAAALDH1A1CYP1A2HPGD
SCHEMBL16907299 0.82 ALDH1A1 (0.56) TDP1NAAAALDH1A1CYP1A2PAM
SCHEMBL13593710 0.80 TDP1 (0.39) TDP1NAAAALDH1A1CYP1A2GAA
SCHEMBL11469977 0.80 GAA (0.42) TDP1NAAAALDH1A1CYP1A2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4342920-A1 SILICONE CHAIN-CONTAINING POLYMER, COATING COMPOSITION, RESIST COMPOSITION AND ARTICLE DIC CORPORATION (JP) 2024-03-27 EP disclosed
CN-104662004-B Novel rebamipide prodrug, method for producing same, and usage thereof 三进制药株式会社 2017-04-19 CN disclosed
US-20160215022-A1 CELL-PENETRATING COMPSTATIN ANALOGS AND USES THEREOF APELLIS PHARMACEUTICALS, INC. 2016-07-28 US disclosed
US-20160215020-A1 CELL-REACTIVE, LONG-ACTING, OR TARGETED COMPSTATIN ANALOGS AND RELATED COMPOSITIONS AND METHODS APELLIS PHARMACEUTICALS, INC. (US) 2016-07-28 US disclosed
US-20160194359-A1 CELL-REACTIVE, LONG-ACTING, OR TARGETED COMPSTATIN ANALOGS AND RELATED COMPOSITIONS AND METHODS APELLIS PHARMACEUTICALS, INC. 2016-07-07 US disclosed
EP-1698644-B1 FLUORINE-CONTAINING PHOTOCURING COMPOSITION DAINIPPON INK & CHEMICALS (JP) 2013-02-27 EP disclosed
US-7601781-B2 Curable compositions KANEKA CORPORATION (JP) 2009-10-13 US disclosed
US-7592405-B2 Fluorine-containing photocurable composition DIC CORPORATION (JP) 2009-09-22 US disclosed
US-20080177001-A1 CURABLE COMPOSITIONS KANEKA CORPORATION (JP) 2008-07-24 US disclosed
US-7304110-B2 Polymer, process for producing the polymer and curable composition containing the polymer KANEKA CORPORATION (JP) 2007-12-04 US disclosed
US-20070066779-A1 Fluorine-containing photocurable composition DIC CORPORATION (JP) 2007-03-22 US disclosed
EP-1698644-A1 FLUORINE-CONTAINING PHOTOCURING COMPOSITION DAINIPPON INK AND CHEMICALS, INC. (JP) 2006-09-06 EP disclosed
EP-1278747-A1 PYRANO, PIPERIDINO, AND THIOPYRANO COMPOUNDS AND METHODS OF USE Abbott Laboratories (US) 2003-01-29 EP disclosed
WO-2001083484-A1 PYRANO, PIPERIDINO, AND THIOPYRANO COMPOUNDS AND METHODS OF USE ABBOTT LABORATORIES (US) 2001-11-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160215022-A1 CELL-PENETRATING COMPSTATIN ANALOGS AND USES THEREOF C9, C3AR1, SERPINC1 TDP1 2394/4885NAAA 1237/4885ALDH1A1 4856/4885
US-20160215020-A1 CELL-REACTIVE, LONG-ACTING, OR TARGETED COMPSTATIN ANALOGS AND RELATED COMPOSITIONS AND METHODS C3AR1, C9, C1QBP TDP1 1714/4885NAAA 1882/4885ALDH1A1 4770/4885
US-20160194359-A1 CELL-REACTIVE, LONG-ACTING, OR TARGETED COMPSTATIN ANALOGS AND RELATED COMPOSITIONS AND METHODS C3AR1, C9, C1QBP TDP1 1719/4885NAAA 1884/4885ALDH1A1 4770/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.