SCHEMBL3868237

SCHEMBL3868237

CCCCO[Si](c1ccc(C)cc1)(c1ccc(C)cc1)c1ccc(C)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.36
KMT2A Q03164 3/20 0.36
DRD2 P14416 1/20 0.36
DRD4 P21917 1/20 0.36
DRD3 P35462 1/20 0.36
CYP2D6 P10635 2/20 0.35
CYP3A4 P08684 1/20 0.35
SMN1; SMN2 Q16637 3/20 0.35
NPC1 O15118 3/20 0.35
RAB9A P51151 3/20 0.35
CYP2C19 P33261 3/20 0.35
HTT P42858 2/20 0.35
CYP1A2 P05177 2/20 0.35
TSHR P16473 1/20 0.35
TLR8 Q9NR97 1/20 0.34
ALDH1A1 P00352 2/20 0.34
MITF O75030 1/20 0.34
LMNA P02545 1/20 0.34
CYP19A1 P11511 2/20 0.33
CYP2C9 P11712 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3867721 0.88 ACHE (0.35) MEN1KMT2ADRD2DRD4DRD3
SCHEMBL3878874 0.84 DRD2 (0.36) MEN1KMT2ADRD2DRD4DRD3
SCHEMBL3876744 0.84 DRD2 (0.36) MEN1KMT2ADRD2DRD4DRD3
SCHEMBL708046 0.84 DUT (0.46) CYP2D6CYP3A4CYP2C19CYP1A2TSHR
SCHEMBL705748 0.82 DUT (0.47) CYP2D6CYP3A4CYP2C19CYP1A2TSHR
SCHEMBL3482024 0.81 DUT (0.38) MEN1KMT2ADRD2DRD4DRD3
SCHEMBL3867374 0.79 ACHE (0.38) MEN1KMT2ASMN1; SMN2NPC1RAB9A
SCHEMBL977974 0.74 CYP2D6 (0.39) CYP2D6CYP3A4SMN1; SMN2NPC1RAB9A
P-Xylene SCHEMBL27374298 0.73 TSHR (0.50) MEN1KMT2ADRD2DRD4DRD3
SCHEMBL12458329 0.73 DRD2 (0.50) MEN1KMT2ADRD2DRD4DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7129311-B2 Additives to prevent degradation of alkyl-hydrogen siloxanes ARCH SPECIALTY CHEMICALS, INC. (US) 2006-10-31 US claimed
US-20060159861-A1 Additives to prevent degradation of alkyl-hydrogen siloxanes ARCH SPECIALTY CHEMICALS, INC. (US) 2006-07-20 US claimed
EP-1573086-A2 ADDITIVES TO PREVENT DEGRADATION OF ALKYL-HYDROGEN SILOXANES Arch Specialty Chemicals, Inc. (US) 2005-09-14 EP claimed
US-20040127070-A1 Additives to prevent degradation of alkyl-hydrogen siloxanes ARCH SPECIALTY CHEMICALS, INC. 2004-07-01 US claimed
WO-2004027110-A2 ADDITIVES TO PREVENT DEGRADATION OF ALKYL-HYDROGEN SILOXANES ARCH SPECIALTY CHEMICALS, INC. (US) 2004-04-01 WO claimed
US-7531590-B2 Additives to prevent degradation of alkyl-hydrogen siloxanes FUJIFILM ELECTRONIC MATERIALS U.S.A., INC. (US) 2009-05-12 US disclosed
US-20060270787-A1 Additives to prevent degradation of alkyl-hydrogen siloxanes VERSUM MATERIALS US, LLC 2006-11-30 US disclosed
US-7129311-B2 Additives to prevent degradation of alkyl-hydrogen siloxanes ARCH SPECIALTY CHEMICALS, INC. (US) 2006-10-31 US disclosed
US-20060159861-A1 Additives to prevent degradation of alkyl-hydrogen siloxanes ARCH SPECIALTY CHEMICALS, INC. (US) 2006-07-20 US disclosed
EP-1573086-A2 ADDITIVES TO PREVENT DEGRADATION OF ALKYL-HYDROGEN SILOXANES Arch Specialty Chemicals, Inc. (US) 2005-09-14 EP disclosed
US-20040127070-A1 Additives to prevent degradation of alkyl-hydrogen siloxanes ARCH SPECIALTY CHEMICALS, INC. 2004-07-01 US disclosed
WO-2004027110-A2 ADDITIVES TO PREVENT DEGRADATION OF ALKYL-HYDROGEN SILOXANES ARCH SPECIALTY CHEMICALS, INC. (US) 2004-04-01 WO disclosed