Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | HPGD | P15428 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 7/20 | 0.70 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 4/20 | 0.68 |
| ▸ | APEX1 | P27695 | 1/20 | 0.68 |
| ▸ | RECQL | P46063 | 1/20 | 0.68 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.66 |
| ▸ | TP53 | P04637 | 4/20 | 0.64 |
| ▸ | THRB | P10828 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | PRNP | P04156 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2160827 | 0.87 | MAPT (0.65) | ALDH1A1HPGDMAPTSHMT2POLB | |
| SCHEMBL9811110 | 0.87 | ALDH1A1 (0.67) | ALDH1A1HPGDMAPTPOLBAPEX1 | |
| SCHEMBL10759434 | 0.86 | ALDH1A1 (0.74) | ALDH1A1HPGDMAPTPOLBAPEX1 | |
| SCHEMBL10759553 | 0.86 | POLB (0.75) | ALDH1A1HPGDMAPTPOLBAPEX1 | |
| SCHEMBL10759558 | 0.84 | MAPT (0.72) | ALDH1A1HPGDMAPTPOLBAPEX1 | |
| SCHEMBL9213780 | 0.83 | MAPT (0.62) | ALDH1A1HPGDMAPTSHMT2POLB | |
| SCHEMBL9218073 | 0.83 | MAPT (0.65) | ALDH1A1HPGDMAPTSHMT2POLB | |
| SCHEMBL19385934 | 0.83 | HPGD (0.69) | ALDH1A1HPGDMAPTPOLBAPEX1 | |
| SCHEMBL615683 | 0.82 | MAPT (1.00) | ALDH1A1HPGDMAPTSHMT2POLB | |
| SCHEMBL9811040 | 0.82 | ALDH1A1 (0.55) | ALDH1A1HPGDMAPTSHMT2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-7025863-A | — | — | None | — | — | JP | disclosed |
| WO-2022198777-A1 | APPLICATION OF TRIAZOLE COMPOUND IN PREPARATION OF ANTITUMOR DRUGS | 苏州大学 | 2022-09-29 | — | — | WO | disclosed |
| CN-111808003-A | Preparation method of thioether | 甘肃农业大学 | 2020-10-23 | — | — | CN | disclosed |
| EP-2800748-B1 | CYCLIC AMIDE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE AND USES THEREOF | CONNEXIOS LIFE SCIENCES PVT LTD (IN) | 2017-03-29 | — | — | EP | disclosed |
| US-9453014-B2 | Cyclic amide derivatives as inhibitors of 11-β-hydroxysteroid dehydrogenase and uses thereof | CONNEXIOS LIFE SCIENCES PVT. LTD. (IN) | 2016-09-27 | — | — | US | disclosed |
| US-9453014-B2 | Cyclic amide derivatives as inhibitors of 11-β-hydroxysteroid dehydrogenase and uses thereof | CONNEXIOS LIFE SCIENCES PVT. LTD. (IN) | 2016-09-27 | — | — | US | disclosed |
| US-20150158860-A1 | CYCLIC AMIDE DERIVATIVES AS INHIBITORS OF 11 - BETA - HYDROXYSTEROID DEHYDROGENASE AND USES THEREOF | CONNEXIOS LIFE SCIENCES PVT. LTD. (IN) | 2015-06-11 | — | — | US | disclosed |
| US-20150158860-A1 | CYCLIC AMIDE DERIVATIVES AS INHIBITORS OF 11 - BETA - HYDROXYSTEROID DEHYDROGENASE AND USES THEREOF | CONNEXIOS LIFE SCIENCES PVT. LTD. (IN) | 2015-06-11 | — | — | US | disclosed |
| JP-H0725863-A | NEW ONIUM SALT COMPOUND AND POLYMERIZATION INITIATOR | NIPPON SODA CO LTD | 1995-01-27 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150158860-A1 | CYCLIC AMIDE DERIVATIVES AS INHIBITORS OF 11 - BETA - HYDROXYSTEROID DEHYDROGENASE AND USES THEREOF | HSD11B1, HSD11B2, HSD17B1 | ALDH1A1 282/4885HPGD 41/4885MAPT 4547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.