Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | GRK2 | P25098 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | QPCT | Q16769 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2911873 | 0.98 | CA2 (0.46) | CA2CAMK2AAKR1B1LMNAGAA | |
| SCHEMBL833000 | 0.82 | HIF1A (0.43) | CA2HIF1AHRH3 | |
| Bromide SCHEMBL3874747 | 0.80 | CHKA (0.55) | CA2CAMK2AAKR1B1LMNAGAA | |
| SCHEMBL2912607 | 0.78 | CHKA (0.53) | CA2CAMK2AAKR1B1LMNAGAA | |
| SCHEMBL840566 | 0.76 | HIF1A (0.59) | HIF1A | |
| SCHEMBL14951080 | 0.76 | HIF1A (0.39) | HIF1AMAPTHRH3 | |
| Water SCHEMBL16037174 | 0.74 | HIF1A (0.57) | HIF1A | |
| Bromide SCHEMBL3874702 | 0.73 | MAPT (0.41) | CA2CAMK2AAKR1B1LMNAGAA | |
| SCHEMBL2911826 | 0.71 | MAPT (0.42) | CA2CAMK2AAKR1B1LMNAGAA | |
| SCHEMBL13714805 | 0.71 | LMNA (0.43) | LMNAALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579339-B2 | Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-08-25 | — | — | US | disclosed |
| US-7407938-B2 | 1,4-Diphenyl-3-(3-hydroxy-3-phenylpropyl)-2-azetidinones, e.g., 2,3,4,5,6-Pentahydroxyhexylamide of 4-(4-{4-[3-[3-(4-fluorophenyl)-3-hydroxypropyl]-2-(4-methoxyphenyl)-4-oxoazetidin-1-y]lbenzylcarbamoyl}phenoxy)benzoic acid; antilipemic agents that have intestinal absorption of less than 10%, | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-08-05 | — | — | US | disclosed |
| US-7390790-B2 | Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-06-24 | — | — | US | disclosed |
| US-20070043017-A1 | Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use | SANOFI-AVENTIS DEUTSCHLAND GMBH | 2007-02-22 | — | — | US | disclosed |
| US-20070037787-A1 | 1,4-Diphenyl-3-(3-hydroxy-3-phenylpropyl)-2-azetidinones, e.g., 2,3,4,5,6-Pentahydroxyhexylamide of 4-(4-{4-[3-[3-(4-fluorophenyl)-3-hydroxypropyl]-2-(4-methoxyphenyl)-4-oxoazetidin-1-y]lbenzylcarbamoyl}phenoxy)benzoic acid; antilipemic agents that have intestinal absorption of less than 10%, | SANOFI-AVENTIS DEUTSCHLAND GMBH | 2007-02-15 | — | — | US | disclosed |
| US-7176194-B2 | Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-02-13 | — | — | US | disclosed |
| US-20060270613-A1 | Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use | SANOFI-AVENTIS DEUTSCHLAND GMBH | 2006-11-30 | — | — | US | disclosed |
| US-20040082561-A1 | Ring -substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043017-A1 | Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use | QDPR, CYP2D6, DHCR7 | CA2 3214/4885CAMK2A 3861/4885AKR1B1 124/4885 |
| US-20040082561-A1 | Ring -substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use | QDPR, CYP2D6, DHCR7 | CA2 3141/4885CAMK2A 3818/4885AKR1B1 121/4885 |
| US-20060270613-A1 | Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use | QDPR, CYP2D6, DHCR7 | CA2 3214/4885CAMK2A 3861/4885AKR1B1 124/4885 |
| US-20070037787-A1 | 1,4-Diphenyl-3-(3-hydroxy-3-phenylpropyl)-2-azetidinones, e.g., 2,3,4,5,6-Pentahydroxyhexylamide of 4-(4-{4-[3-[3-(4-fluorophenyl)-3-hydroxypropyl]-2-(4-methoxyphenyl)-4-oxoazetidin-1-y]lbenzylcarbamoyl}phenoxy)benzoic acid; antilipemic agents that have intestinal absorption of less than 10%, | HPD, FABP2, CYP2B6 | CA2 1755/4885CAMK2A 4179/4885AKR1B1 204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.