Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.73 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | XDH | P47989 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9520652 | 0.83 | HTR6 (0.73) | HTR6MAPTGAAXDHLMNA | |
| SCHEMBL1590218 | 0.67 | HTR6 (0.50) | HTR6MAPTGAASMN1; SMN2MEN1 | |
| SCHEMBL8124056 | 0.65 | HPGD (0.62) | HTR6MAPTGAAXDHSMN1; SMN2 | |
| SCHEMBL8128304 | 0.62 | MAPT (0.53) | HTR6MAPTGAALMNASMN1; SMN2 | |
| SCHEMBL16561279 | 0.58 | ALDH1A1 (0.50) | MAPTGAAXDHLMNASMN1; SMN2 | |
| SCHEMBL3519585 | 0.57 | XDH (0.50) | HTR6MAPTGAAXDHLMNA | |
| SCHEMBL5940602 | 0.55 | ALDH1A1 (0.49) | HTR6MAPTGAAXDHLMNA | |
| SCHEMBL12012991 | 0.52 | LMNA (0.47) | HTR6MAPTXDHLMNASMN1; SMN2 | |
| SCHEMBL17011660 | 0.51 | — | — | |
| SCHEMBL10520868 | 0.51 | ALDH1A1 (0.32) | ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2116546-A1 | Substituted N-phenyl-2,3-dihydroimidazo[2,1-b]thiazole-5-sulfonamide derivatives as 5-HT6 ligands | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2009-11-11 | — | — | EP | disclosed |