Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.54 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3945346 | 0.94 | RAB9A (0.49) | SCN9ASCN5ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL13425427 | 0.90 | ALOX15 (0.55) | SCN9ASCN5ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL18333417 | 0.87 | GPR84 (0.50) | SCN9ASCN5ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL7769184 | 0.86 | RAB9A (0.51) | SMN1; SMN2LMNAALDH1A1HPGDMAPT | |
| SCHEMBL3952311 | 0.82 | LMNA (0.46) | SCN9ASCN5ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL13946391 | 0.80 | SCN9A (0.40) | SCN9ASCN5ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL11135378 | 0.78 | SMN1; SMN2 (0.59) | SCN9ASCN5ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL9274344 | 0.78 | LMNA (0.57) | SMN1; SMN2LMNAALDH1A1HPGDMAPT | |
| SCHEMBL3879885 | 0.78 | SMN1; SMN2 (0.54) | SCN9ASCN5ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL3526925 | 0.77 | RAB9A (0.53) | SMN1; SMN2LMNAALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118220-A1 | SUBSTITUTED ADENINES AND THE USES THEREOF | ASTRAZENECA AB (SE) | 2009-05-07 | — | — | US | disclosed |
| US-20090118220-A1 | SUBSTITUTED ADENINES AND THE USES THEREOF | ASTRAZENECA AB (SE) | 2009-05-07 | — | — | US | disclosed |
| US-20090118220-A1 | SUBSTITUTED ADENINES AND THE USES THEREOF | ASTRAZENECA AB (SE) | 2009-05-07 | — | — | US | disclosed |
| EP-2010553-A1 | SUBSTITUTED ADENINES AND THE USES THEREOF | AstraZeneca AB (SE) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007113538-A1 | SUBSTITUTED ADENINES AND THE USES THEREOF | ASTRAZENECA AB (SE) | 2007-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118220-A1 | SUBSTITUTED ADENINES AND THE USES THEREOF | HPRT1, APRT, NUDT1 | SCN9A 2997/4885SCN5A 2656/4885SMN1; SMN2 3124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.