Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.38 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.38 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.38 |
| ▸ | NAAA | Q02083 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 2/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | P4HB | P07237 | 1/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.32 |
| ▸ | ANPEP | P15144 | 1/20 | 0.32 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3886296 | 0.82 | EPHX2 (0.39) | EPHX2PTGER2PTGER3PTGDRNAAA | |
| SCHEMBL3884188 | 0.74 | QPCT (0.35) | ALDH1A1 | |
| SCHEMBL3550353 | 0.70 | DRD2 (0.50) | EPHX2POLBKMT2AHDAC6MAP3K5 | |
| SCHEMBL13205680 | 0.69 | PTGER2 (0.53) | PTGER2PTGER3PTGDRNAAAALDH1A1 | |
| SCHEMBL113722 | 0.69 | EPHX2 (0.61) | EPHX2HDAC6MAP3K5 | |
| SCHEMBL10065847 | 0.65 | PTGER2 (0.64) | PTGER2PTGER3PTGDRALDH1A1KMT2A | |
| SCHEMBL13109270 | 0.65 | PTGER2 (0.64) | PTGER2PTGER3PTGDRALDH1A1KMT2A | |
| SCHEMBL3554203 | 0.64 | RAB9A (0.58) | EPHX2ALDH1A1KMT2AHDAC6 | |
| SCHEMBL821120 | 0.64 | EPHX2 (0.56) | EPHX2 | |
| SCHEMBL11334877 | 0.62 | ALDH1A1 (0.35) | ALDH1A1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010524-A2 | S1P RECEPTOR MODULATING COMPOUNDS | Epix Delaware, Inc. (US) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007109330-A2 | S1P RECEPTOR MODULATING COMPOUNDS | EPIX DELAWARE, INC. (US) | 2007-09-27 | — | — | WO | disclosed |