Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR known ✓ | P00374 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.47 |
| ▸ | VNN1 | O95497 | 4/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3881010 | 0.89 | CDK5 (0.51) | CYP19A1CDK5CDK5R1VNN1CA1 | |
| Potassium Ion SCHEMBL3882943 | 0.89 | HDAC1 (0.51) | CDK5CDK5R1HDAC3HDAC1HDAC2 | |
| Potassium Ion SCHEMBL3877708 | 0.87 | KDM5B (0.52) | CYP19A1CDK5CDK5R1HDAC1HDAC8 | |
| Potassium Ion SCHEMBL3885749 | 0.86 | KDM5B (0.43) | CYP19A1CA1CA2MMP13 | |
| Potassium Ion SCHEMBL3873536 | 0.86 | KDM4A (0.45) | VNN1CA1CA2HDAC1HDAC2 | |
| Potassium Ion SCHEMBL3874287 | 0.81 | KDM5B (0.45) | CYP19A1CA2NPC1RAB9A | |
| SCHEMBL3878702 | 0.78 | SMN1; SMN2 (0.54) | CDK5CDK5R1HDAC3HDAC1HDAC2 | |
| Potassium Ion SCHEMBL3874312 | 0.78 | KDM4A (0.55) | CA1CA2 | |
| Potassium Ion SCHEMBL3886555 | 0.77 | KDM4C (0.48) | VNN1HDAC3HDAC1HDAC2MMP13 | |
| SCHEMBL3873546 | 0.76 | KDM5B (0.51) | CYP19A1CDK5CDK5R1HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910305-B1 | IMIDAZOLE DERIVATIVES AS FRUCTOSE-1,6-BISPHOSPHATASE INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK PATENT GMBH (DE) | 2009-08-26 | — | — | EP | claimed |