Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 2/20 | 0.45 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.45 |
| ▸ | KDM5A | P29375 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | KDM4B | O94953 | 1/20 | 0.40 |
| ▸ | KDM5C | P41229 | 1/20 | 0.40 |
| ▸ | VNN1 | O95497 | 4/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL3877708 | 0.90 | KDM5B (0.52) | KDM4AKDM5BKDM5AKDM4CKDM4B | |
| Potassium Ion SCHEMBL3885749 | 0.89 | KDM5B (0.43) | KDM4AKDM5BKDM5AKDM4CCA1 | |
| SCHEMBL3881934 | 0.88 | KDM5A (0.55) | KDM4AKDM5BKDM5AKDM4CVNN1 | |
| Potassium Ion SCHEMBL3879744 | 0.86 | CYP19A1 (0.47) | CA1CA2VNN1HDAC1HDAC2 | |
| Potassium Ion SCHEMBL3874287 | 0.83 | KDM5B (0.45) | KDM4AKDM5BKDM5AKDM4CCA2 | |
| Potassium Ion SCHEMBL3886555 | 0.81 | KDM4C (0.48) | KDM4AKDM5BKDM4CKDM4BKDM5C | |
| Potassium Ion SCHEMBL3877293 | 0.81 | HDAC6 (0.36) | KDM4AKDM5BKDM5AKDM4CKDM4B | |
| Potassium Ion SCHEMBL3874312 | 0.81 | KDM4A (0.55) | KDM4AKDM5BCA1CA2KDM4B | |
| Potassium Ion SCHEMBL3882943 | 0.79 | HDAC1 (0.51) | HDAC1HDAC6ALDH1A1SMN1; SMN2HDAC2 | |
| SCHEMBL3873546 | 0.79 | KDM5B (0.51) | KDM4AKDM5BKDM5AKDM4CKDM4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910305-B1 | IMIDAZOLE DERIVATIVES AS FRUCTOSE-1,6-BISPHOSPHATASE INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK PATENT GMBH (DE) | 2009-08-26 | — | — | EP | claimed |