Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 7/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | ALPI | P09923 | 1/20 | 0.49 |
| ▸ | XIAP | P98170 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38804 | 1.00 | SLC7A5 (0.49) | SLC7A5PTGS1PKMALPIXIAP | |
| SCHEMBL19667341 | 0.90 | SLC7A5 (0.55) | SLC7A5PTGS1PKMALPIXIAP | |
| SCHEMBL2703289 | 0.90 | SLC7A5 (0.55) | SLC7A5PTGS1PKMALPIXIAP | |
| SCHEMBL38535 | 0.90 | SLC7A5 (0.55) | SLC7A5PTGS1PKMALPIXIAP | |
| Hydrochloric Acid SCHEMBL10477486 | 0.88 | SLC7A5 (0.53) | SLC7A5PTGS1PKMALPIXIAP | |
| Hydrochloric Acid SCHEMBL10477485 | 0.88 | SLC7A5 (0.53) | SLC7A5PTGS1PKMALPIXIAP | |
| SCHEMBL5281460 | 0.88 | SLC7A5 (0.57) | SLC7A5PTGS1PKMALPIXIAP | |
| SCHEMBL20889265 | 0.82 | SLC7A5 (0.47) | SLC7A5PTGS1PKMALPIXIAP | |
| Phenylalanine SCHEMBL15966897 | 0.82 | SLC7A5 (0.71) | SLC7A5PTGS1PKMALPIXIAP | |
| SCHEMBL8767255 | 0.80 | SLC7A5 (0.50) | SLC7A5PTGS1PKMALPIXIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104225574-B | METHODS FOR PREVENTING MITOCHONDRIAL PERMEABILITY TRANSITION | 科内尔研究基金会 | 2017-01-11 | — | — | CN | disclosed |
| CN-106163537-A | Cuorin targeting peptides suppression amyloid beta oligomer toxicity | 康奈尔大学 | 2016-11-23 | — | — | CN | disclosed |
| CN-106102760-A | Aromatic-cationic peptides is for treating the purposes of the mitochondria dysfunction of cholesterol induction | 康奈尔大学 | 2016-11-09 | — | — | CN | disclosed |
| CN-106039282-A | AROMATIC-CATIONIC PEPTIDES AND USES OF SAME | 康奈尔大学 | 2016-10-26 | — | — | CN | disclosed |
| CN-105879008-A | METHODS FOR THE PREVENTION OR TREATMENT OF NO-REFLOW FOLLOWING ISCHEMIA/REPERFUSION INJURY | 康德生物医疗技术公司 | 2016-08-24 | — | — | CN | disclosed |
| CN-105753939-A | Aromatic-cationic Peptides And Uses Of Same | 康德生物医疗技术公司 | 2016-07-13 | — | — | CN | disclosed |
| CN-105579054-A | Methods of preventing or treating left ventricular remodeling | STEALTH PEPTIDES INT INC | 2016-05-11 | — | — | CN | disclosed |
| CN-105343869-A | Methods and compositions for preventing or treating ophthalmic conditions | STEALTH PEPTIDES INT INC | 2016-02-24 | — | — | CN | disclosed |
| CN-105056206-A | Methods and compositions for preventing or treating ophthalmic conditions | STEALTH PEPTIDES INT INC | 2015-11-18 | — | — | CN | disclosed |
| CN-104922653-A | Method for treating or preventing skeletal muscle infirmities in mammalian subject | UNIV FLORIDA | 2015-09-23 | — | — | CN | disclosed |
| US-20070010489-A1 | Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds | GILEAD SCIENCES, INC. | 2007-01-11 | — | — | US | disclosed |
| EP-1711617-A1 | METHOD AND COMPOSITIONS FOR IDENTIFYING ANTI-HIV THERAPEUTICS COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2006-10-18 | — | — | EP | disclosed |
| WO-2005064008-A9 | METHOD AND COMPOSITIONS FOR IDENTIFYING ANTI-HIV THERAPEUTIC COMPOUNDS | GILEAD SCIENCES INC (US) | 2006-09-28 | — | — | WO | disclosed |
| EP-1599216-A2 | METHODS FOR PREVENTING MITOCHONDRIAL PERMEABILITY TRANSITION | CORNELL RESEARCH FOUNDATION, INC. (US) | 2005-11-30 | — | — | EP | disclosed |
| US-20050239054-A1 | Method and compositions for identifying anti-HIV therapeutic compounds | GILEAD SCIENCES. INC. | 2005-10-27 | — | — | US | disclosed |
| US-20050209197-A1 | Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds | GILEAD SCIENCES, INC. | 2005-09-22 | — | — | US | disclosed |
| WO-2005064008-A1 | METHOD AND COMPOSITIONS FOR IDENTIFYING ANTI-HIV THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2005-07-14 | — | — | WO | disclosed |
| EP-1509537-A2 | CELLULAR ACCUMULATION OF PHOSPHONATE ANALOGS OF HIV PROTEASE INHIBITOR COMPOUNDS AND THE COMPOUNDS AS SUCH | GILEAD SCIENCES, INC. (US) | 2005-03-02 | — | — | EP | disclosed |
| WO-2004070054-A2 | METHODS FOR PREVENTING MITOCHONDRIAL PERMEABILITY TRANSITION | CORNELL RESEARCH FOUNDATION, INC. (US) | 2004-08-19 | — | — | WO | disclosed |
| WO-2003090690-A2 | CELLULAR ACCUMULATION OF PHOSPHONATE ANALOGS OF HIV PROTEASE INHIBITOR COMPOUNDS AND THE COMPOUNDS AS SUCH | GILEAD SCIENCES, INC. (US) | 2003-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209197-A1 | Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds | PPA1, PPME1, PNP | SLC7A5 2206/4885PTGS1 3381/4885PKM 894/4885 |
| US-20050239054-A1 | Method and compositions for identifying anti-HIV therapeutic compounds | CES1, PNP, PGLS | SLC7A5 3230/4885PTGS1 2951/4885PKM 2444/4885 |
| US-20070010489-A1 | Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds | PPA1, PNP, PPME1 | SLC7A5 1918/4885PTGS1 3372/4885PKM 880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.